| Reaction Details |
|---|
 | Report a problem with these data |
| Target | PAS domain-containing serine/threonine-protein kinase |
|---|
| Ligand | BDBM463499 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | FRET Assay |
|---|
| IC50 | <1000±n/a nM |
|---|
| Citation |  McCall, JM; Romero, DL; McKearn, J; Clare, M Heterocyclic compounds for the inhibition of PASK US Patent US10781185 Publication Date 9/22/2020 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| PAS domain-containing serine/threonine-protein kinase |
|---|
| Name: | PAS domain-containing serine/threonine-protein kinase |
|---|
| Synonyms: | KIAA0135 | PAS-kinase | PASK | PASKIN | PASK_HUMAN | hPASK |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 142867.26 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_944230 |
|---|
| Residue: | 1323 |
|---|
| Sequence: | MEDGGLTAFEEDQRCLSQSLPLPVSAEGPAAQTTAEPSRSFSSAHRHLSRRNGLSRLCQS
RTALSEDRWSSYCLSSLAAQNICTSKLHCPAAPEHTDPSEPRGSVSCCSLLRGLSSGWSS
PLLPAPVCNPNKAIFTVDAKTTEILVANDKACGLLGYSSQDLIGQKLTQFFLRSDSDVVE
ALSEEHMEADGHAAVVFGTVVDIISRSGEKIPVSVWMKRMRQERRLCCVVVLEPVERVST
WVAFQSDGTVTSCDSLFAHLHGYVSGEDVAGQHITDLIPSVQLPPSGQHIPKNLKIQRSV
GRARDGTTFPLSLKLKSQPSSEEATTGEAAPVSGYRASVWVFCTISGLITLLPDGTIHGI
NHSFALTLFGYGKTELLGKNITFLIPGFYSYMDLAYNSSLQLPDLASCLDVGNESGCGER
TLDPWQGQDPAEGGQDPRINVVLAGGHVVPRDEIRKLMESQDIFTGTQTELIAGGQLLSC
LSPQPAPGVDNVPEGSLPVHGEQALPKDQQITALGREEPVAIESPGQDLLGESRSEPVDV
KPFASCEDSEAPVPAEDGGSDAGMCGLCQKAQLERMGVSGPSGSDLWAGAAVAKPQAKGQ
LAGGSLLMHCPCYGSEWGLWWRSQDLAPSPSGMAGLSFGTPTLDEPWLGVENDREELQTC
LIKEQLSQLSLAGALDVPHAELVPTECQAVTAPVSSCDLGGRDLCGGCTGSSSACYALAT
DLPGGLEAVEAQEVDVNSFSWNLKELFFSDQTDQTSSNCSCATSELRETPSSLAVGSDPD
VGSLQEQGSCVLDDRELLLLTGTCVDLGQGRRFRESCVGHDPTEPLEVCLVSSEHYAASD
RESPGHVPSTLDAGPEDTCPSAEEPRLNVQVTSTPVIVMRGAAGLQREIQEGAYSGSCYH
RDGLRLSIQFEVRRVELQGPTPLFCCWLVKDLLHSQRDSAARTRLFLASLPGSTHSTAAE
LTGPSLVEVLRARPWFEEPPKAVELEGLAACEGEYSQKYSTMSPLGSGAFGFVWTAVDKE
KNKEVVVKFIKKEKVLEDCWIEDPKLGKVTLEIAILSRVEHANIIKVLDIFENQGFFQLV
MEKHGSGLDLFAFIDRHPRLDEPLASYIFRQLVSAVGYLRLKDIIHRDIKDENIVIAEDF
TIKLIDFGSAAYLERGKLFYTFCGTIEYCAPEVLMGNPYRGPELEMWSLGVTLYTLVFEE
NPFCELEETVEAAIHPPYLVSKELMSLVSGLLQPVPERRTTLEKLVTDPWVTQPVNLADY
TWEEVFRVNKPESGVLSAASLEMGNRSLSDVAQAQELCGGPVPGEAPNGQGCLHPGDPRL
LTS
|
|
|
|---|
| BDBM463499 |
|---|
| n/a |
|---|
| Name | BDBM463499 |
|---|
| Synonyms: | 2-(2,3-Dihydrobenzo[b][1,4]dioxin-6-yl)-3-(isopropyl(methyl)amino)quinoxaline-6-carboxylic acid | US10781185, Example 81 | US11459307, Example 81 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C21H21N3O4 |
|---|
| Mol. Mass. | 379.4091 |
|---|
| SMILES | CC(C)N(C)c1nc2cc(ccc2nc1-c1ccc2OCCOc2c1)C(O)=O |
|---|
| Structure | 
|
|---|
Search and Browse
