Reaction Details |
| Report a problem with these data |
Target | Glycogen synthase kinase-3 beta |
---|
Ligand | BDBM7422 |
---|
Substrate/Competitor | GSK-3 Peptide Substrate |
---|
Meas. Tech. | Kinase Inhibition Assay |
---|
Temperature | 303.15±n/a K |
---|
IC50 | 7±n/a nM |
---|
Comments | extracted |
---|
Citation | Polychronopoulos, P; Magiatis, P; Skaltsounis, AL; Myrianthopoulos, V; Mikros, E; Tarricone, A; Musacchio, A; Roe, SM; Pearl, L; Leost, M; Greengard, P; Meijer, L Structural basis for the synthesis of indirubins as potent and selective inhibitors of glycogen synthase kinase-3 and cyclin-dependent kinases. J Med Chem47:935-46 (2004) [PubMed] Article |
---|
More Info.: | Get all data from this article, Solution Info, Assay Method |
---|
|
Glycogen synthase kinase-3 beta |
---|
Name: | Glycogen synthase kinase-3 beta |
Synonyms: | GSK-3 alpha/beta | Glycogen Synthase Kinase-3, beta |
Type: | Enzyme Mixture |
Mol. Mass.: | 48062.20 |
Organism: | Porcine |
Description: | Purification of GSK-3 alpha and GSK-3 beta from Porcine
Brain on Axin-Sepharose. Porcine brains were obtained from a local slaughter and directly homogenized and processed for affinity chromatography. |
Residue: | 433 |
Sequence: | MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTK
VIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSG
EKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHR
DIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDV
WSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHP
WTKDSSGTGHFTSGVRVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPN
VKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPSNATAASDTNAGDRGQ
TNNTASASASNST
|
|
|
BDBM7422 |
---|
GSK-3 Peptide Substrate |
---|
Name: | GSK-3 Peptide Substrate |
Synonyms: | GS-1 Peptide | Phospho-GS2 Substrate Peptide |
Type: | Peptide |
Mol. Mass.: | 3045.17 |
Organism: | n/a |
Description: | n/a |
Residue: | 27 |
Sequence: | YRRAAVPPSPSLSRHSSPHQS(PO4)EDEEE
|
|
|