| Reaction Details |
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 | Report a problem with these data |
| Target | Neutral amino acid transporter B(0) |
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| Ligand | BDBM464430 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | 3H-Amino Acid Uptake Assays |
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| IC50 | 22500±n/a nM |
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| Citation |  Manning, HC; Schulte, M Glutamine transport inhibitors and methods for treating cancer US Patent US10793514 Publication Date 10/6/2020 |
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| More Info.: | Get all data from this article, Assay Method |
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| Neutral amino acid transporter B(0) |
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| Name: | Neutral amino acid transporter B(0) |
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| Synonyms: | AAAT_HUMAN | ASCT2 | ASCT2 | ATB(0) | Baboon M7 virus receptor | M7V1 | Neutral amino acid transporter B(0) | RD114/simian type D retrovirus receptor | RDR | RDRC | SLC1A5 | Sodium-dependent neutral amino acid transporter type 2 | Solute carrier family 1 member 5 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 56592.12 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_109758 |
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| Residue: | 541 |
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| Sequence: | MVADPPRDSKGLAAAEPTANGGLALASIEDQGAAAGGYCGSRDQVRRCLRANLLVLLTVV
AVVAGVALGLGVSGAGGALALGPERLSAFVFPGELLLRLLRMIILPLVVCSLIGGAASLD
PGALGRLGAWALLFFLVTTLLASALGVGLALALQPGAASAAINASVGAAGSAENAPSKEV
LDSFLDLARNIFPSNLVSAAFRSYSTTYEERNITGTRVKVPVGQEVEGMNILGLVVFAIV
FGVALRKLGPEGELLIRFFNSFNEATMVLVSWIMWYAPVGIMFLVAGKIVEMEDVGLLFA
RLGKYILCCLLGHAIHGLLVLPLIYFLFTRKNPYRFLWGIVTPLATAFGTSSSSATLPLM
MKCVEENNGVAKHISRFILPIGATVNMDGAALFQCVAAVFIAQLSQQSLDFVKIITILVT
ATASSVGAAGIPAGGVLTLAIILEAVNLPVDHISLILAVDWLVDRSCTVLNVEGDALGAG
LLQNYVDRTESRSTEPELIQVKSELPLDPLPVPTEEGNPLLKHYRGPAGDATVASEKESV
M
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| BDBM464430 |
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| n/a |
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| Name | BDBM464430 |
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| Synonyms: | US10793514, Compound 23 |
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| Type | Small organic molecule |
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| Emp. Form. | C34H32F6N2O4 |
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| Mol. Mass. | 646.6193 |
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| SMILES | N[C@H](CCN(Cc1ccccc1OCc1cccc(c1)C(F)(F)F)Cc1ccccc1OCc1cccc(c1)C(F)(F)F)C(O)=O |r| |
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| Structure | 
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