| Reaction Details |
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 | Report a problem with these data |
| Target | Glutamate dehydrogenase 2, mitochondrial |
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| Ligand | BDBM383191 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Modified Recombinant Enzyme Assay |
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| IC50 | 33.0±n/a nM |
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| Citation |  Li, J; Chen, L; Goyal, B; Laidig, G; Stanton, TF; Sjogren, EB Heterocyclic glutaminase inhibitors US Patent US10793535 Publication Date 10/6/2020 |
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| More Info.: | Get all data from this article, Assay Method |
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| Glutamate dehydrogenase 2, mitochondrial |
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| Name: | Glutamate dehydrogenase 2, mitochondrial |
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| Synonyms: | DHE4_HUMAN | GDH 2 | GLUD2 | GLUDP1 |
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| Type: | Protein |
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| Mol. Mass.: | 61446.88 |
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| Organism: | Human |
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| Description: | P49448 |
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| Residue: | 558 |
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| Sequence: | MYRYLAKALLPSRAGPAALGSAANHSAALLGRGRGQPAAASQPGLALAARRHYSELVADR
EDDPNFFKMVEGFFDRGASIVEDKLVKDLRTQESEEQKRNRVRGILRIIKPCNHVLSLSF
PIRRDDGSWEVIEGYRAQHSQHRTPCKGGIRYSTDVSVDEVKALASLMTYKCAVVDVPFG
GAKAGVKINPKNYTENELEKITRRFTMELAKKGFIGPGVDVPAPDMNTGEREMSWIADTY
ASTIGHYDINAHACVTGKPISQGGIHGRISATGRGVFHGIENFINEASYMSILGMTPGFR
DKTFVVQGFGNVGLHSMRYLHRFGAKCIAVGESDGSIWNPDGIDPKELEDFKLQHGSILG
FPKAKPYEGSILEVDCDILIPAATEKQLTKSNAPRVKAKIIAEGANGPTTPEADKIFLER
NILVIPDLYLNAGGVTVSYFEWLKNLNHVSYGRLTFKYERDSNYHLLLSVQESLERKFGK
HGGTIPIVPTAEFQDSISGASEKDIVHSALAYTMERSARQIMHTAMKYNLGLDLRTAAYV
NAIEKVFKVYSEAGVTFT
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| BDBM383191 |
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| n/a |
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| Name | BDBM383191 |
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| Synonyms: | US10278968, Compound 719 | US10793535, Cmpd ID 719 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H23F4N7O3S |
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| Mol. Mass. | 589.565 |
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| SMILES | Fc1ccc(CC(=O)Nc2ccc(CCCCc3nnc(NC(=O)Cc4ccccn4)s3)nn2)cc1OC(F)(F)F |
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| Structure | 
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