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TargetNon-receptor tyrosine-protein kinase TYK2 [556-888]
LigandBDBM399696
Substrate/Competitorn/a
Meas. Tech.TYK2 JH2 Domain Binding Assay
Kd 5.5±n/a nM
Citation Greenwood, JRHarriman, GCLeit de Moradei, SMMasse, CEMcLean, THMondal, S TYK2 inhibitors and uses thereof US Patent US10793574 Publication Date 10/6/2020
More Info.:Get all data from this article,  Assay Method
 
Non-receptor tyrosine-protein kinase TYK2 [556-888]
Name:Non-receptor tyrosine-protein kinase TYK2 [556-888]
Synonyms:Non-receptor tyrosine-protein kinase TYK2 (G556-D888) | Non-receptor tyrosine-protein kinase TYK2 (aa 556-888) | TYK2 | TYK2 JH2 Domain (aa 556-888) | TYK2_HUMAN
Type:Protein
Mol. Mass.:36941.98
Organism:Homo sapiens (Human)
Description:P29597 (aa 556-888)
Residue:333
Sequence:
GETSNLIIMRGARASPRTLNLSQLSFHRVDQKEITQLSHLGQGTRTNVYEGRLRVEGSGD
PEEGKMDDEDPLVPGRDRGQELRVVLKVLDPSHHDIALAFYETASLMSQVSHTHLAFVHG
VCVRGPENIMVTEYVEHGPLDVWLRRERGHVPMAWKMVVAQQLASALSYLENKNLVHGNV
CGRNILLARLGLAEGTSPFIKLSDPGVGLGALSREERVERIPWLAPECLPGGANSLSTAM
DKWGFGATLLEICFDGEAPLQSRSPSEKEHFYQRQHRLPEPSCPQLATLTSQCLTYEPTQ
RPSFRTILRDLTRLQPHNLADVLTVNPDSPASD
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM399696
n/a
NameBDBM399696
Synonyms:US10323036, Compound I-140 | US10793574, Compound I-140 | US11220508, Compound I-140
TypeSmall organic molecule
Emp. Form.C23H25N7O4S
Mol. Mass.495.554
SMILESCOC1CN(C1)c1cccc(Nc2cc(Nc3ccccc3S(C)(=O)=O)c3c(n2)[nH]n(C)c3=O)n1
Structure
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