| Reaction Details |
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 | Report a problem with these data |
| Target | Non-receptor tyrosine-protein kinase TYK2 [556-888] |
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| Ligand | BDBM399712 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | TYK2 JH2 Domain Binding Assay |
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| Kd | 0.3±n/a nM |
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| Citation |  Greenwood, JR; Harriman, GC; Leit de Moradei, SM; Masse, CE; McLean, TH; Mondal, S TYK2 inhibitors and uses thereof US Patent US10793574 Publication Date 10/6/2020 |
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| More Info.: | Get all data from this article, Assay Method |
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| Non-receptor tyrosine-protein kinase TYK2 [556-888] |
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| Name: | Non-receptor tyrosine-protein kinase TYK2 [556-888] |
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| Synonyms: | Non-receptor tyrosine-protein kinase TYK2 (G556-D888) | Non-receptor tyrosine-protein kinase TYK2 (aa 556-888) | TYK2 | TYK2 JH2 Domain (aa 556-888) | TYK2_HUMAN |
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| Type: | Protein |
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| Mol. Mass.: | 36941.98 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P29597 (aa 556-888) |
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| Residue: | 333 |
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| Sequence: | GETSNLIIMRGARASPRTLNLSQLSFHRVDQKEITQLSHLGQGTRTNVYEGRLRVEGSGD
PEEGKMDDEDPLVPGRDRGQELRVVLKVLDPSHHDIALAFYETASLMSQVSHTHLAFVHG
VCVRGPENIMVTEYVEHGPLDVWLRRERGHVPMAWKMVVAQQLASALSYLENKNLVHGNV
CGRNILLARLGLAEGTSPFIKLSDPGVGLGALSREERVERIPWLAPECLPGGANSLSTAM
DKWGFGATLLEICFDGEAPLQSRSPSEKEHFYQRQHRLPEPSCPQLATLTSQCLTYEPTQ
RPSFRTILRDLTRLQPHNLADVLTVNPDSPASD
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| BDBM399712 |
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| n/a |
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| Name | BDBM399712 |
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| Synonyms: | US10323036, Compound I-182 | US10793574, Compound I-182 | US11220508, Compound I-182 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H25N5O4S |
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| Mol. Mass. | 455.53 |
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| SMILES | Cn1[nH]c2nc(NC(=O)C3CC3)cc(Nc3ccc(cc3S(C)(=O)=O)C3CCC3)c2c1=O |
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| Structure | 
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