| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Tyrosine-protein kinase JAK2 |
|---|
| Ligand | BDBM466347 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | JAK Kinase Assays |
|---|
| EC50 | 1.10±n/a nM |
|---|
| Citation |  Larsen, M; Ritzen, A; Nørremark, B; Greve, DR 5-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-5-azaspiro[2.5]octane-8-carboxylic acid derivatives as novel JAK kinase inhibitors US Patent US10799507 Publication Date 10/13/2020 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Tyrosine-protein kinase JAK2 |
|---|
| Name: | Tyrosine-protein kinase JAK2 |
|---|
| Synonyms: | JAK-2 | JAK2 | JAK2_HUMAN | Janus kinase 2 | Janus kinase 2 (JAK2) | Janus kinase 2 (a protein tyrosine kinase) |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 130684.68 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | O60674 |
|---|
| Residue: | 1132 |
|---|
| Sequence: | MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSG
EYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPNHVFHIDESTRHNVLYRIRFYF
PRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLG
MAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQF
SQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSR
GKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLR
EALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQT
GLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEYNLSGTKKNFSSLKDLLNC
YQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKI
RNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASM
MSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWA
MHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVP
PECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAEL
ANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRD
PTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIE
ILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQI
CKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFW
YAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIE
LLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG
|
|
|
|---|
| BDBM466347 |
|---|
| n/a |
|---|
| Name | BDBM466347 |
|---|
| Synonyms: | (8S)—N-[(1S,2S)-2-Cyclopentyl-2-Hydroxy-1-Methyl-Ethyl]-5-(7H-Pyrrolo[2,3-d]-Pyrimidin-4-Yl)-5-Azaspiro[2.5]Octane-8-Carboxamide | US10799507, Example 5 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C22H31N5O2 |
|---|
| Mol. Mass. | 397.5138 |
|---|
| SMILES | C[C@H](NC(=O)[C@H]1CCN(CC11CC1)c1ncnc2[nH]ccc12)[C@@H](O)C1CCCC1 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
