| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Tyrosine-protein kinase JAK1 |
|---|
| Ligand | BDBM466489 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | JAK Kinase Assays |
|---|
| EC50 | 0.900±n/a nM |
|---|
| Citation |  Larsen, M; Ritzen, A; Nørremark, B; Greve, DR 5-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-5-azaspiro[2.5]octane-8-carboxylic acid derivatives as novel JAK kinase inhibitors US Patent US10799507 Publication Date 10/13/2020 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Tyrosine-protein kinase JAK1 |
|---|
| Name: | Tyrosine-protein kinase JAK1 |
|---|
| Synonyms: | JAK-1 | JAK1 | JAK1A | JAK1B | JAK1_HUMAN | Janus kinase 1 | Janus kinase 1 (JAK1) | Janus kinase 1 JAK1 |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 133293.73 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P23458 |
|---|
| Residue: | 1154 |
|---|
| Sequence: | MQYLNIKEDCNAMAFCAKMRSSKKTEVNLEAPEPGVEVIFYLSDREPLRLGSGEYTAEEL
CIRAAQACRISPLCHNLFALYDENTKLWYAPNRTITVDDKMSLRLHYRMRFYFTNWHGTN
DNEQSVWRHSPKKQKNGYEKKKIPDATPLLDASSLEYLFAQGQYDLVKCLAPIRDPKTEQ
DGHDIENECLGMAVLAISHYAMMKKMQLPELPKDISYKRYIPETLNKSIRQRNLLTRMRI
NNVFKDFLKEFNNKTICDSSVSTHDLKVKYLATLETLTKHYGAEIFETSMLLISSENEMN
WFHSNDGGNVLYYEVMVTGNLGIQWRHKPNVVSVEKEKNKLKRKKLENKHKKDEEKNKIR
EEWNNFSYFPEITHIVIKESVVSINKQDNKKMELKLSSHEEALSFVSLVDGYFRLTADAH
HYLCTDVAPPLIVHNIQNGCHGPICTEYAINKLRQEGSEEGMYVLRWSCTDFDNILMTVT
CFEKSEQVQGAQKQFKNFQIEVQKGRYSLHGSDRSFPSLGDLMSHLKKQILRTDNISFML
KRCCQPKPREISNLLVATKKAQEWQPVYPMSQLSFDRILKKDLVQGEHLGRGTRTHIYSG
TLMDYKDDEGTSEEKKIKVILKVLDPSHRDISLAFFEAASMMRQVSHKHIVYLYGVCVRD
VENIMVEEFVEGGPLDLFMHRKSDVLTTPWKFKVAKQLASALSYLEDKDLVHGNVCTKNL
LLAREGIDSECGPFIKLSDPGIPITVLSRQECIERIPWIAPECVEDSKNLSVAADKWSFG
TTLWEICYNGEIPLKDKTLIEKERFYESRCRPVTPSCKELADLMTRCMNYDPNQRPFFRA
IMRDINKLEEQNPDIVSEKKPATEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDN
TGEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLP
SGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIG
DFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLTYCDS
DSSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRT
SFQNLIEGFEALLK
|
|
|
|---|
| BDBM466489 |
|---|
| n/a |
|---|
| Name | BDBM466489 |
|---|
| Synonyms: | (3,3-Difluorocyclobutyl)Methyl (8S)-5-(7H-Pyrrolo[2,3-d]Pyrimidin-4-Yl)-5-Azaspiro[2.5]Octane-8-Carboxylate | US10799507, Example 154 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C19H22F2N4O2 |
|---|
| Mol. Mass. | 376.4004 |
|---|
| SMILES | FC1(F)CC(COC(=O)[C@H]2CCN(CC22CC2)c2ncnc3[nH]ccc23)C1 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
