| Reaction Details |
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 | Report a problem with these data |
| Target | Vasopressin V2 receptor |
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| Ligand | BDBM466531 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Cellular In Vitro Assay for Determining Vasopressin V2 Receptor Activity |
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| IC50 | 2.80±n/a nM |
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| Citation |  Schmeck, C; Engelen, A; Kolkhof, P; Lustig, K; Pook, E; Wasnaire, P Oxoalkyl-substituted phenyltriazole derivatives and uses thereof US Patent US10800746 Publication Date 10/13/2020 |
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| More Info.: | Get all data from this article, Assay Method |
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| Vasopressin V2 receptor |
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| Name: | Vasopressin V2 receptor |
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| Synonyms: | ADHR | AVPR V2 | AVPR2 | Antidiuretic hormone receptor | DIR | DIR3 | Renal-type arginine vasopressin receptor | V2R | V2R_HUMAN | VASOPRESSIN V2 | Vasopressin V2 receptor | Vasopressin receptor |
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| Type: | Receptor |
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| Mol. Mass.: | 40295.28 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P30518 |
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| Residue: | 371 |
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| Sequence: | MLMASTTSAVPGHPSLPSLPSNSSQERPLDTRDPLLARAELALLSIVFVAVALSNGLVLA
ALARRGRRGHWAPIHVFIGHLCLADLAVALFQVLPQLAWKATDRFRGPDALCRAVKYLQM
VGMYASSYMILAMTLDRHRAICRPMLAYRHGSGAHWNRPVLVAWAFSLLLSLPQLFIFAQ
RNVEGGSGVTDCWACFAEPWGRRTYVTWIALMVFVAPTLGIAACQVLIFREIHASLVPGP
SERPGGRRRGRRTGSPGEGAHVSAAVAKTVRMTLVIVVVYVLCWAPFFLVQLWAAWDPEA
PLEGAPFVLLMLLASLNSCTNPWIYASFSSSVSSELRSLLCCARGRTPPSLGPQDESCTT
ASSSLAKDTSS
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| BDBM466531 |
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| n/a |
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| Name | BDBM466531 |
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| Synonyms: | 5-(4-Chlorophenyl)-2-({1-(3-chlorophenyl)-5-[(1S,R)-1-hydroxyethyl]-1H-1,2,4-triazol-3-yl}methyl)-4-(3,3,3-trifluoro-2-oxopropyl)-2,4-dihydro-3H-1,2,4-triazol-3-one | US10800746, Example 5 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H17Cl2F3N6O3 |
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| Mol. Mass. | 541.31 |
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| SMILES | CC(O)c1nc(Cn2nc(-c3ccc(Cl)cc3)n(CC(=O)C(F)(F)F)c2=O)nn1-c1cccc(Cl)c1 |
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| Structure | 
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