Reaction Details |
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Target | Glycogen synthase kinase-3 beta |
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Ligand | BDBM7434 |
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Substrate/Competitor | GSK-3 Peptide Substrate |
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Meas. Tech. | Kinase Inhibition Assay |
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pH | 7.5±n/a |
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Temperature | 303.15±n/a K |
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IC50 | >10000±n/a nM |
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Citation | Laronze, M; Boisbrun, M; Leonce, S; Pfeiffer, B; Renard, P; Lozach, O; Meijer, L; Lansiaux, A; Bailly, C; Sapi, J; Laronze, JY Synthesis and anticancer activity of new pyrrolocarbazoles and pyrrolo-beta-carbolines. Bioorg Med Chem13:2263-83 (2005) [PubMed] Article |
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More Info.: | Get all data from this article, Solution Info, Assay Method |
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Glycogen synthase kinase-3 beta |
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Name: | Glycogen synthase kinase-3 beta |
Synonyms: | GSK-3 alpha/beta | Glycogen Synthase Kinase-3, beta |
Type: | Enzyme Mixture |
Mol. Mass.: | 48062.20 |
Organism: | Porcine |
Description: | Purification of GSK-3 alpha and GSK-3 beta from Porcine
Brain on Axin-Sepharose. Porcine brains were obtained from a local slaughter and directly homogenized and processed for affinity chromatography. |
Residue: | 433 |
Sequence: | MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTK
VIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSG
EKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHR
DIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDV
WSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHP
WTKDSSGTGHFTSGVRVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPN
VKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPSNATAASDTNAGDRGQ
TNNTASASASNST
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BDBM7434 |
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GSK-3 Peptide Substrate |
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Name: | GSK-3 Peptide Substrate |
Synonyms: | GS-1 Peptide | Phospho-GS2 Substrate Peptide |
Type: | Peptide |
Mol. Mass.: | 3045.17 |
Organism: | n/a |
Description: | n/a |
Residue: | 27 |
Sequence: | YRRAAVPPSPSLSRHSSPHQS(PO4)EDEEE
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