| Reaction Details |
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 | Report a problem with these data |
| Target | Histone acetyltransferase KAT8 [177-447] |
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| Ligand | US11911372, Example 6 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Acetyltransferase Biochemical Assay |
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| IC50 | 746±n/a nM |
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| Citation |  Stupple, PA; Lagiakos, HR; Foitzik, RC; Camerino, MA; Nikolakopoulos, G; Bozikis, YE; Kersten, WJ; Walker, SR; Hubert, JG Compounds US Patent US11911372 Publication Date 2/27/2024 |
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| More Info.: | Get all data from this article, Assay Method |
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| Histone acetyltransferase KAT8 [177-447] |
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| Name: | Histone acetyltransferase KAT8 |
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| Synonyms: | KAT8 | KAT8_HUMAN | Lysine acetyltransferase 8 | MOF | MOZ, YBF2/SAS3, SAS2 and TIP60 protein 1 | MYST-1 | MYST1 | hMOF |
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| Type: | PROTEIN |
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| Mol. Mass.: | 52413.66 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_796800 |
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| Residue: | 458 |
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| Sequence: | MAAQGAAAAVAAGTSGVAGEGEPGPGENAAAEGTAPSPGRVSPPTPARGEPEVTVEIGET
YLCRRPDSTWHSAEVIQSRVNDQEGREEFYVHYVGFNRRLDEWVDKNRLALTKTVKDAVQ
KNSEKYLSELAEQPERKITRNQKRKHDEINHVQKTYAEMDPTTAALEKEHEAITKVKYVD
KIHIGNYEIDAWYFSPFPEDYGKQPKLWLCEYCLKYMKYEKSYRFHLGQCQWRQPPGKEI
YRKSNISVYEVDGKDHKIYCQNLCLLAKLFLDHKTLYFDVEPFVFYILTEVDRQGAHIVG
YFSKEKESPDGNNVACILTLPPYQRRGYGKFLIAFSYELSKLESTVGSPEKPLSDLGKLS
YRSYWSWVLLEILRDFRGTLSIKDLSQMTSITQNDIISTLQSLNMVKYWKGQHVICVTPK
LVEEHLKSAQYKKPPITVDSVCLKWAPPKHKQVKLSKK
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| US11911372, Example 6 |
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| n/a |
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| Name | US11911372, Example 6 |
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| Synonyms: | n/a |
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| Type | Small organic molecule |
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| Emp. Form. | C25H24N2O7S |
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| Mol. Mass. | 496.532 |
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| SMILES | COc1ccc(OC)c(c1)-c1cc(NS(=O)(=O)c2c(OC)cc(cc2OC)-c2ccccc2)no1 |
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| Structure | 
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