| Reaction Details |
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 | Report a problem with these data |
| Target | Adenosine receptor A2a |
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| Ligand | BDBM471639 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Competition Binding Assay |
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| Ki | 0.800±n/a nM |
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| Citation |  Ali, A; Huang, X; Lim, Y; Kuang, R; Wu, H; Anand, R; Yu, Y; Metzger, E; Man-Chu Lo, M; Ting, PC; Stamford, AW; Tempest, P Substituted aminoquinazoline compounds as A2A antagonist US Patent US10822338 Publication Date 11/3/2020 |
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| More Info.: | Get all data from this article, Assay Method |
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| Adenosine receptor A2a |
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| Name: | Adenosine receptor A2a |
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| Synonyms: | A2A adenosine receptor (hA2A) | AA2AR_HUMAN | ADENOSINE A2 | ADENOSINE A2a | ADORA2 | ADORA2A | Adenosine A2A receptor (A2AAR) |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 44716.46 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P29274 |
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| Residue: | 412 |
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| Sequence: | MPIMGSSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAI
PFAITISTGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTR
AKGIIAICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYF
NFFACVLVPLLLMLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVG
LFALCWLPLHIINCFTFFCPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFR
KIIRSHVLRQQEPFKAAGTSARVLAAHGSDGEQVSLRLNGHPPGVWANGSAPHPERRPNG
YALGLVSGGSAQESQGNTGLPDVELLSHELKGVCPEPPGLDDPLAQDGAGVS
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| BDBM471639 |
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| n/a |
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| Name | BDBM471639 |
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| Synonyms: | (R)-7-methoxy-2-(1-(5- methylthiazol-2- yl)piperidin-3-yl)- [1,2,4]triazolo[1,5- c]quinazolin-5-amine | US10822338, Example 22 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H21N7OS |
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| Mol. Mass. | 395.481 |
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| SMILES | COc1cccc2c3nc(nn3c(N)nc12)[C@@H]1CCCN(C1)c1ncc(C)s1 |r| |
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| Structure | 
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