| Reaction Details |
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 | Report a problem with these data |
| Target | Bcl-2-like protein 11 [72-87] |
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| Ligand | BDBM361573 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Fluorescence Polarization Assay |
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| IC50 | 0.760±n/a nM |
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| Citation |  Wang, S; Chen, J N-(phenylsulfonyl)benzamides and related compounds as bcl-2 inhibitors US Patent US10829488 Publication Date 11/10/2020 |
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| More Info.: | Get all data from this article, Assay Method |
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| Bcl-2-like protein 11 [72-87] |
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| Name: | Bcl-2-like protein 11 [72-87] |
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| Synonyms: | B2L11_HUMAN | BCL2L11 | BIM | Bcl-2 homologous antagonist/killer (BAK)(72-87) |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 1724.92 |
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| Organism: | Homo sapiens (Human) |
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| Description: | aa 72-87 |
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| Residue: | 16 |
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| Sequence: | |
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| BDBM361573 |
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| n/a |
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| Name | BDBM361573 |
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| Synonyms: | 2-((1H-pyrrolo[2,3-b]pyridin-5-yl)oxy)-4-(4-((6-(4- chlorophenyl)-2-oxaspiro[3.5]non-6-en-7- yl)methyl)piperazin-1-yl)-N-((3-nitro-4- (((tetrahydro-2H-pyran-4- yl)methyl)amino)phenyl)sulfonyl)benzamide | US10221174, Compound 2 | US10829488, Compound 2 | US11718613, Compound 2 |
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| Type | Small organic molecule |
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| Emp. Form. | C45H48ClN7O8S |
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| Mol. Mass. | 882.423 |
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| SMILES | [O-][N+](=O)c1cc(ccc1NCC1CCOCC1)S(=O)(=O)NC(=O)c1ccc(cc1Oc1cnc2[nH]ccc2c1)N1CCN(CC2=C(CC3(COC3)CC2)c2ccc(Cl)cc2)CC1 |t:49| |
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| Structure | 
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