| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Cyclin-dependent kinase 6/G1/S-specific cyclin-D1 [L188C] |
|---|
| Ligand | BDBM472673 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Inhibition In Vitro Assay |
|---|
| IC50 | 30600±n/a nM |
|---|
| Citation |  Strum, JC; Jung, D Substituted dihydropyrazino[1 ′,2′:1,5]pyrrolo[2,3-d]pyrimidine-based antiproliferative agents US Patent US10829490 Publication Date 11/10/2020 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Cyclin-dependent kinase 6/G1/S-specific cyclin-D1 [L188C] |
|---|
| Name: | Cyclin-dependent kinase 6/G1/S-specific cyclin-D1 [L188C] |
|---|
| Synonyms: | CDK6/Cyclin D | Cyclin-Dependent Kinase 6 (CDK6) |
|---|
| Type: | Protein Complex |
|---|
| Mol. Mass.: | n/a |
|---|
| Description: | n/a |
|---|
| Components: | This complex has 2 components. |
|---|
| Component 1 |
| Name: | Cyclin-dependent kinase 6 |
|---|
| Synonyms: | CDK6 | CDK6_HUMAN | CDKN6 | Cell division protein kinase 6 | Cyclin-dependent kinase 6 (CDK 6) | Serine/threonine-protein kinase PLSTIRE |
|---|
| Type: | Enzyme Subunit |
|---|
| Mol. Mass.: | 36937.42 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q00534 |
|---|
| Residue: | 326 |
|---|
| Sequence: | MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIR
EVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTE
TIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVV
VTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGE
EDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYF
QDLERCKENLDSHLPPSQNTSELNTA
|
|
|
|---|
| Component 2 |
| Name: | G1/S-specific cyclin-D1 [L188C] |
|---|
| Synonyms: | BCL1 | CCND1 | CCND1_HUMAN | Cyclin D | PRAD1 |
|---|
| Type: | Enzyme Subunit |
|---|
| Mol. Mass.: | 33634.57 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P24385[L188C] |
|---|
| Residue: | 295 |
|---|
| Sequence: | MEHQLLCCEVETIRRAYPDANLLNDRVLRAMLKAEETCAPSVSYFKCVQKEVLPSMRKIV
ATWMLEVCEEQKCEEEVFPLAMNYLDRFLSLEPVKKSRLQLLGATCMFVASKMKETIPLT
AEKLCIYTDGSIRPEELLQMELLLVNKLKWNLAAMTPHDFIEHFLSKMPEAEENKQIIRK
HAQTFVASCATDVKFISNPPSMVAAGSVVAAVQGLNLRSPNNFLSYYRLTRFLSRVIKCD
PDCLRACQEQIEALLESSLRQAQQNMDPKAAEEEEEEEEEVDLACTPTDVRDVDI
|
|
|
|---|
| BDBM472673 |
|---|
| n/a |
|---|
| Name | BDBM472673 |
|---|
| Synonyms: | 10,10-dimethyl-2-((5-(4- methylpiperazin-1-yl)pyridin-2- yl)amino)-6,6a,9,10-tetrahydro- 5H-pyrazino[1',2':1,6]pyrido[2,3- d]pyrimidine-5,7(8H)-dione | US10829490, Cmpd # 1 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C22H28N8O2 |
|---|
| Mol. Mass. | 436.5101 |
|---|
| SMILES | CN1CCN(CC1)c1ccc(Nc2ncc3C(=O)CC4N(c3n2)C(C)(C)CNC4=O)nc1 |
|---|
| Structure | 
|
|---|
Search and Browse
