| Reaction Details |
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 | Report a problem with these data |
| Target | Platelet-derived growth factor receptor alpha [D842V] |
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| Ligand | BDBM469288 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Biochemical Enzymatic Activity |
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| IC50 | <0.30±n/a nM |
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| Citation |  Dineen, TA Compositions and methods for treating KIT- and PDGFRA-mediated diseases US Patent US10829493 Publication Date 11/10/2020 |
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| More Info.: | Get all data from this article, Assay Method |
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| Platelet-derived growth factor receptor alpha [D842V] |
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| Name: | Platelet-derived growth factor receptor alpha [D842V] |
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| Synonyms: | PDGFR2 | PDGFRA | PGFRA_HUMAN | Platelet-derived growth factor receptor (D842V) | Platelet-derived growth factor receptor alpha (PDGFR)(D842V) | Platelet-derived growth factor receptor alpha (PDGFRα)(D842V) | RHEPDGFRA |
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| Type: | Protein |
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| Mol. Mass.: | 122618.43 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P16234 (D842V) |
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| Residue: | 1089 |
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| Sequence: | MGTSHPAFLVLGCLLTGLSLILCQLSLPSILPNENEKVVQLNSSFSLRCFGESEVSWQYP
MSEEESSDVEIRNEENNSGLFVTVLEVSSASAAHTGLYTCYYNHTQTEENELEGRHIYIY
VPDPDVAFVPLGMTDYLVIVEDDDSAIIPCRTTDPETPVTLHNSEGVVPASYDSRQGFNG
TFTVGPYICEATVKGKKFQTIPFNVYALKATSELDLEMEALKTVYKSGETIVVTCAVFNN
EVVDLQWTYPGEVKGKGITMLEEIKVPSIKLVYTLTVPEATVKDSGDYECAARQATREVK
EMKKVTISVHEKGFIEIKPTFSQLEAVNLHEVKHFVVEVRAYPPPRISWLKNNLTLIENL
TEITTDVEKIQEIRYRSKLKLIRAKEEDSGHYTIVAQNEDAVKSYTFELLTQVPSSILDL
VDDHHGSTGGQTVRCTAEGTPLPDIEWMICKDIKKCNNETSWTILANNVSNIITEIHSRD
RSTVEGRVTFAKVEETIAVRCLAKNLLGAENRELKLVAPTLRSELTVAAAVLVLLVIVII
SLIVLVVIWKQKPRYEIRWRVIESISPDGHEYIYVDPMQLPYDSRWEFPRDGLVLGRVLG
SGAFGKVVEGTAYGLSRSQPVMKVAVKMLKPTARSSEKQALMSELKIMTHLGPHLNIVNL
LGACTKSGPIYIITEYCFYGDLVNYLHKNRDSFLSHHPEKPKKELDIFGLNPADESTRSY
VILSFENNGDYMDMKQADTTQYVPMLERKEVSKYSDIQRSLYDRPASYKKKSMLDSEVKN
LLSDDNSEGLTLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLAQGKIVKICDFGLA
RVIMHDSNYVSKGSTFLPVKWMAPESIFDNLYTTLSDVWSYGILLWEIFSLGGTPYPGMM
VDSTFYNKIKSGYRMAKPDHATSEVYEIMVKCWNSEPEKRPSFYHLSEIVENLLPGQYKK
SYEKIHLDFLKSDHPAVARMRVDSDNAYIGVTYKNEEDKLKDWEGGLDEQRLSADSGYII
PLPDIDPVPEEEDLGKRNRHSSQTSEESAIETGSSSSTFIKREDETIEDIDMMDDIGIDS
SDLVEDSFL
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| BDBM469288 |
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| n/a |
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| Name | BDBM469288 |
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| Synonyms: | US10807985, Compound 63 | US10829493, Example 63 of WO2015/057873 |
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| Type | Small organic molecule |
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| Emp. Form. | C27H29FN10 |
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| Mol. Mass. | 512.5846 |
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| SMILES | CCn1cc(cn1)-c1cc2c(ncnn2c1)N1CCN(CC1)c1ncc(cn1)[C@@](C)(N)c1ccc(F)cc1 |r| |
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| Structure | 
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