| Reaction Details |
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 | Report a problem with these data |
| Target | Substance-K receptor |
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| Ligand | BDBM242754 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Human NK-2 assay |
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| Ki | >30000±n/a nM |
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| Citation |  Hoveyda, H; Dutheuil, G; Fraser, G N-acyl-(3-substituted)-(8-substituted)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazines as selective NK-3 receptor antagonists US Patent US10836768 Publication Date 11/17/2020 |
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| More Info.: | Get all data from this article, Assay Method |
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| Substance-K receptor |
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| Name: | Substance-K receptor |
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| Synonyms: | NK-2 receptor | NK-2R | NK2R | NK2R_HUMAN | NKNAR | Neurokinin 2 receptor | Neurokinin A receptor | Neurokinin NK2 | Neurokinin-2 (NK-2) | Neuromedin-2 receptor (NK-2R) | SKR | TAC2R | TACR2 | Tachykinin receptor 2 | Tachykinin receptor 2 (NK2) | hnk-3 |
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| Type: | Protein |
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| Mol. Mass.: | 44455.78 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P21452 |
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| Residue: | 398 |
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| Sequence: | MGTCDIVTEANISSGPESNTTGITAFSMPSWQLALWATAYLALVLVAVTGNAIVIWIILA
HRRMRTVTNYFIVNLALADLCMAAFNAAFNFVYASHNIWYFGRAFCYFQNLFPITAMFVS
IYSMTAIAADRYMAIVHPFQPRLSAPSTKAVIAGIWLVALALASPQCFYSTVTMDQGATK
CVVAWPEDSGGKTLLLYHLVVIALIYFLPLAVMFVAYSVIGLTLWRRAVPGHQAHGANLR
HLQAMKKFVKTMVLVVLTFAICWLPYHLYFILGSFQEDIYCHKFIQQVYLALFWLAMSST
MYNPIIYCCLNHRFRSGFRLAFRCCPWVTPTKEDKLELTPTTSLSTRVNRCHTKETLFMA
GDTAPSEATSGEAGRPQDGSGLWFGYGLLAPTKTHVEI
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|
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| BDBM242754 |
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| n/a |
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| Name | BDBM242754 |
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| Synonyms: | US10030025, Compound 18 | US10836768, Cpd no 18 | US11731974, Compound 18 | US9422299, 18 | US9987274, Compound 18 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H14F2N6OS |
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| Mol. Mass. | 376.384 |
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| SMILES | C[C@H]1N(CCn2c1nnc2-c1nc(C)ns1)C(=O)c1ccc(F)cc1F |r| |
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| Structure | 
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