Ki Summary

Reaction Details

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Target

Induced myeloid leukemia cell differentiation protein Mcl-1 [172-327]

Ligand

BDBM50160010

Substrate/Competitor

n/a

Meas. Tech.

Binding Assay

<100.0±n/a nM

Citation

Lee, T; Pelz, NF; Belmar, J; Bian, Z; Olejniczak, ET; Fesik, SW; Chauder, BA Substituted benzofuran, benzothiophene and indole Mcl-1 inhibitors US Patent US10844032 Publication Date 11/24/2020

More Info.:

Get all data from this article, Assay Method

Induced myeloid leukemia cell differentiation protein Mcl-1 [172-327]

Name:

Induced myeloid leukemia cell differentiation protein Mcl-1 [172-327]

Synonyms:

Type:

n/a

Mol. Mass.:

17768.02

Organism:

Homo sapiens (Human)

Description:

Q07820[172-327]

Residue:

156

Sequence:

DELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGM
LRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLA
ESITDVLVRTKRDWLVKQRGWDGFVEFFHVEDLEGG

BDBM50160010

n/a

Name

BDBM50160010

Synonyms:

CHEMBL3786147 | US10093640, Example 305 | US10844032, Example 305

Type

Small organic molecule

Emp. Form.

C31H31ClN4O4S

Mol. Mass.

591.12

SMILES

Cc1n[nH]c(C)c1-c1cccc2c(CCCOc3cc(C)c(Cl)c(C)c3)c([nH]c12)C(=O)NS(=O)(=O)c1ccccc1 |(-3.43,3.61,;-2.26,3.99,;-1.77,5.45,;-.23,5.43,;.23,3.96,;1.4,3.56,;-1.02,3.09,;-1.03,1.55,;-2.38,.77,;-2.38,-.77,;-1.03,-1.55,;.3,-.77,;1.76,-1.24,;2.24,-2.7,;3.75,-3.01,;4.24,-4.47,;5.75,-4.78,;6.23,-6.24,;7.74,-6.56,;8.22,-8.02,;9.43,-8.27,;7.2,-9.17,;7.58,-10.34,;5.69,-8.86,;4.87,-9.77,;5.21,-7.39,;2.66,.02,;1.76,1.24,;.3,.77,;4.2,.04,;4.83,-1.02,;4.95,1.38,;6.49,1.4,;7.12,.35,;5.89,.33,;7.24,2.75,;8.78,2.77,;9.54,4.11,;8.75,5.44,;7.21,5.42,;6.46,4.07,)|

Structure