| Reaction Details |
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 | Report a problem with these data |
| Target | Tyrosine-protein kinase HCK |
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| Ligand | BDBM473748 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Inhibition Assay |
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| IC50 | 0.730±n/a nM |
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| Citation |  Gray, NS; Buhrlage, SJ; Treon, SP; Choi, HG; Xiong, Y; Yang, G Thiazolyl-containing compounds for treating proliferative diseases US Patent US10844077 Publication Date 11/24/2020 |
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| More Info.: | Get all data from this article, Assay Method |
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| Tyrosine-protein kinase HCK |
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| Name: | Tyrosine-protein kinase HCK |
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| Synonyms: | HCK | HCK_HUMAN | Hematopoietic cell kinase | Hemopoietic cell kinase | p59-HCK/p60-HCK | p59Hck | p61Hck |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 59600.18 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P08631 |
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| Residue: | 526 |
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| Sequence: | MGGRSSCEDPGCPRDEERAPRMGCMKSKFLQVGGNTFSKTETSASPHCPVYVPDPTSTIK
PGPNSHNSNTPGIREAGSEDIIVVALYDYEAIHHEDLSFQKGDQMVVLEESGEWWKARSL
ATRKEGYIPSNYVARVDSLETEEWFFKGISRKDAERQLLAPGNMLGSFMIRDSETTKGSY
SLSVRDYDPRQGDTVKHYKIRTLDNGGFYISPRSTFSTLQELVDHYKKGNDGLCQKLSVP
CMSSKPQKPWEKDAWEIPRESLKLEKKLGAGQFGEVWMATYNKHTKVAVKTMKPGSMSVE
AFLAEANVMKTLQHDKLVKLHAVVTKEPIYIITEFMAKGSLLDFLKSDEGSKQPLPKLID
FSAQIAEGMAFIEQRNYIHRDLRAANILVSASLVCKIADFGLARVIEDNEYTAREGAKFP
IKWTAPEAINFGSFTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALERGYRMPRPE
NCPEELYNIMMRCWKNRPEERPTFEYIQSVLDDFYTATESQYQQQP
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| BDBM473748 |
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| n/a |
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| Name | BDBM473748 |
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| Synonyms: | US10844077, Compound I-2 |
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| Type | Small organic molecule |
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| Emp. Form. | C28H34N8O3S |
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| Mol. Mass. | 562.686 |
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| SMILES | Cc1cccc(C)c1NC(=O)c1cnc(Nc2cc(CN3CCOCC3)nc(N[C@H]3CCN(C3)C(=O)C=C)n2)s1 |r| |
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| Structure | 
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