| Reaction Details |
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 | Report a problem with these data |
| Target | Monoglyceride lipase |
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| Ligand | BDBM474404 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | MAGL Enzymatic Assay (30 minute) |
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| IC50 | 1.000±n/a nM |
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| Citation |  Brodney, MA; Butler, CR; McAllister, LA; Helal, CJ; O''Neil, SV; Verhoest, PR Heterocyclic spiro compounds as MAGL inhibitors US Patent US10858373 Publication Date 12/8/2020 |
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| More Info.: | Get all data from this article, Assay Method |
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| Monoglyceride lipase |
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| Name: | Monoglyceride lipase |
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| Synonyms: | HU-K5 | Lysophospholipase homolog | Lysophospholipase-like | MAGL | MGL | MGLL | MGLL_HUMAN |
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| Type: | Hydrolase |
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| Mol. Mass.: | 33264.56 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Human recombinant MGL (Cayman Chemical, cat# 10008354). |
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| Residue: | 303 |
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| Sequence: | MPEESSPRRTPQSIPYQDLPHLVNADGQYLFCRYWKPTGTPKALIFVSHGAGEHSGRYEE
LARMLMGLDLLVFAHDHVGHGQSEGERMVVSDFHVFVRDVLQHVDSMQKDYPGLPVFLLG
HSMGGAIAILTAAERPGHFAGMVLISPLVLANPESATTFKVLAAKVLNLVLPNLSLGPID
SSVLSRNKTEVDIYNSDPLICRAGLKVCFGIQLLNAVSRVERALPKLTVPFLLLQGSADR
LCDSKGAYLLMELAKSQDKTLKIYEGAYHVLHKELPEVTNSVFHEINMWVSQRTATAGTA
SPP
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| BDBM474404 |
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| n/a |
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| Name | BDBM474404 |
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| Synonyms: | 1,1,1,3,3,3-Hexafluoropropan-2-yl 4-[(4-fluorophenyl)sulfonyl]-1-oxa-4,9-diazaspiro[5.5]undecane-9-carboxylate | US10858373, Example 2 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H19F7N2O5S |
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| Mol. Mass. | 508.408 |
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| SMILES | Fc1ccc(cc1)S(=O)(=O)N1CCOC2(CCN(CC2)C(=O)OC(C(F)(F)F)C(F)(F)F)C1 |
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| Structure | 
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