| Reaction Details |
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 | Report a problem with these data |
| Target | Ataxin-1 |
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| Ligand | BDBM475941 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ATX Inhibition |
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| IC50 | 1.40±n/a nM |
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| Citation |  Auberson, Y; Briard, E; Le Grand, D; Oberhauser, B Pet imaging agents US Patent US10865195 Publication Date 12/15/2020 |
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| More Info.: | Get all data from this article, Assay Method |
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| Ataxin-1 |
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| Name: | Ataxin-1 |
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| Synonyms: | ATX1 | ATX1_HUMAN | ATXN1 | SCA1 |
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| Type: | Protein |
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| Mol. Mass.: | 86941.25 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P54253 |
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| Residue: | 815 |
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| Sequence: | MKSNQERSNECLPPKKREIPATSRSSEEKAPTLPSDNHRVEGTAWLPGNPGGRGHGGGRH
GPAGTSVELGLQQGIGLHKALSTGLDYSPPSAPRSVPVATTLPAAYATPQPGTPVSPVQY
AHLPHTFQFIGSSQYSGTYASFIPSQLIPPTANPVTSAVASAAGATTPSQRSQLEAYSTL
LANMGSLSQTPGHKAEQQQQQQQQQQQQHQHQQQQQQQQQQQQQQHLSRAPGLITPGSPP
PAQQNQYVHISSSPQNTGRTASPPAIPVHLHPHQTMIPHTLTLGPPSQVVMQYADSGSHF
VPREATKKAESSRLQQAIQAKEVLNGEMEKSRRYGAPSSADLGLGKAGGKSVPHPYESRH
VVVHPSPSDYSSRDPSGVRASVMVLPNSNTPAADLEVQQATHREASPSTLNDKSGLHLGK
PGHRSYALSPHTVIQTTHSASEPLPVGLPATAFYAGTQPPVIGYLSGQQQAITYAGSLPQ
HLVIPGTQPLLIPVGSTDMEASGAAPAIVTSSPQFAAVPHTFVTTALPKSENFNPEALVT
QAAYPAMVQAQIHLPVVQSVASPAAAPPTLPPYFMKGSIIQLANGELKKVEDLKTEDFIQ
SAEISNDLKIDSSTVERIEDSHSPGVAVIQFAVGEHRAQVSVEVLVEYPFFVFGQGWSSC
CPERTSQLFDLPCSKLSVGDVCISLTLKNLKNGSVKKGQPVDPASVLLKHSKADGLAGSR
HRYAEQENGINQGSAQMLSENGELKFPEKMGLPAAPFLTKIEPSKPAATRKRRWSAPESR
KLEKSEDEPPLTLPKPSLIPQEVKICIEGRSNVGK
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| BDBM475941 |
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| n/a |
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| Name | BDBM475941 |
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| Synonyms: | US10865195, Compound 6 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H25F4N7O2 |
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| Mol. Mass. | 507.4839 |
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| SMILES | C[C@@H]1CN(Cc2coc(CF)n2)CCN1C(=O)\C=C\c1ccc(cc1Cn1nnc(C)n1)C(F)(F)F |r| |
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| Structure | 
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