Reaction Details |
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Target | Cyclin-dependent kinase 7 |
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Ligand | BDBM395718 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Kinase Activity Assay |
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IC50 | 550±n/a nM |
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Citation | Ciblat, S; Kabro, A; Leblanc, M; Leger, S; Marineau, JJ; Miller, T; Roy, S; Schmidt, D; Siddiqui, MA; Sprott, K; Winter, DK; Ripka, A; Li, D; Zhang, G Inhibitors of cyclin-dependent kinase 7 (CDK7) US Patent US10865206 Publication Date 12/15/2020 |
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More Info.: | Get all data from this article, Assay Method |
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Cyclin-dependent kinase 7 |
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Name: | Cyclin-dependent kinase 7 |
Synonyms: | 39 kDa protein kinase | CAK | CAK1 | CDK-activating kinase | CDK-activating kinase 1 (CAK) | CDK7 | CDK7_HUMAN | CDKN7 | Cell division protein kinase 7 | Cyclin-Dependent Kinase 7 (CDK7) | Cyclin-dependent kinase 7 (CDK7/cyclin H) | MO15 | P39 Mo15 | STK1 | TFIIH basal transcription factor complex kinase subunit |
Type: | Enzyme Subunit |
Mol. Mass.: | 39047.01 |
Organism: | Homo sapiens (Human) |
Description: | n/a |
Residue: | 346 |
Sequence: | MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTAL
REIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLM
TLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRA
PELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDM
CSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPG
PTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF
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BDBM395718 |
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n/a |
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Name | BDBM395718 |
Synonyms: | N1-(4-(((1S,3R)-3-((5-chloro-4-(1H-indol-3-yl)pyrimidin-2-yl)amino)cyclohexyl)carbamoyl)phenyl)oxalamide | US10308648, Compound 113 | US10865206, Compound 113 |
Type | Small organic molecule |
Emp. Form. | C27H26ClN7O3 |
Mol. Mass. | 531.993 |
SMILES | NC(=O)C(=O)Nc1ccc(cc1)C(=O)N[C@H]1CCC[C@H](C1)Nc1ncc(Cl)c(n1)-c1c[nH]c2ccccc12 |r| |
Structure |
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