Ki Summary

Reaction Details

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Target

D(3) dopamine receptor

Ligand

BDBM476861

Substrate/Competitor

n/a

Meas. Tech.

Binding Assay

0.200±n/a nM

Citation

Tobinaga, H; Masuda, K; Inagaki, M; Yonehara, M; Masuda, M Nitrogen-containing condensed ring compounds having dopamine D3 antagonistic effect US Patent US10870660 Publication Date 12/22/2020

More Info.:

Get all data from this article, Assay Method

D(3) dopamine receptor

Name:

D(3) dopamine receptor

Synonyms:

Type:

n/a

Mol. Mass.:

44243.43

Organism:

Homo sapiens (Human)

Description:

n/a

Residue:

400

Sequence:

MASLSQLSSHLNYTCGAENSTGASQARPHAYYALSYCALILAIVFGNGLVCMAVLKERAL
QTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILN
LCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGDPTV
CSISNPDFVIYSSVVSFYLPFGVTVLVYARIYVVLKQRRRKRILTRQNSQCNSVRPGFPQ
QTLSPDPAHLELKRYYSICQDTALGGPGFQERGGELKREEKTRNSLSPTIAPKLSLEVRK
LSNGRLSTSLKLGPLQPRGVPLREKKATQMVAIVLGAFIVCWLPFFLTHVLNTHCQTCHV
SPELYSATTWLGYVNSALNPVIYTTFNIEFRKAFLKILSC

BDBM476861

n/a

Name

BDBM476861

Synonyms:

US10870660, Compound II-026

Type

Small organic molecule

Emp. Form.

C26H33F2N5O2S

Mol. Mass.

517.634

SMILES

Cn1cc2c(cccc2n1)C(=O)N[C@H]1CC[C@H](CCN2CCc3nc(OCC(F)F)sc3CC2)CC1 |r,wU:16.18,wD:13.14,(12.57,-.99,;11.8,.35,;10.27,.51,;9.95,2.02,;8.61,2.79,;8.61,4.33,;9.95,5.1,;11.28,4.33,;11.28,2.79,;12.42,1.76,;7.28,2.02,;7.28,.48,;5.94,2.79,;4.61,2.02,;3.28,2.79,;1.94,2.02,;1.94,.48,;.61,-.29,;-.72,.48,;-2.06,-.29,;-3.26,.67,;-4.76,.32,;-5.43,-1.06,;-6.96,-1.27,;-7.23,-2.79,;-8.57,-3.56,;-9.9,-2.79,;-11.23,-3.56,;-12.57,-2.79,;-11.23,-5.1,;-5.88,-3.52,;-4.76,-2.45,;-3.26,-2.79,;-2.06,-1.83,;3.28,-.29,;4.61,.48,)|

Structure