| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Programmed cell death 1 ligand/protein 1 |
|---|
| Ligand | BDBM474554 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Homogenous Time-Resolved Fluorescence (HTRF) binding assay |
|---|
| IC50 | 3.0±n/a nM |
|---|
| Citation |  Yeung, K; Grant-Young, KA; Sun, L; Langley, DR; St. Laurent, DR; Scola, PM Compounds useful as immunomodulators US Patent US10882844 Publication Date 1/5/2021 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Programmed cell death 1 ligand/protein 1 |
|---|
| Name: | Programmed cell death 1 ligand/protein 1 |
|---|
| Synonyms: | PD-1/PD-L1 | Programmed cell death protein 1/Programmed cell death 1 ligand 1 |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | n/a |
|---|
| Description: | n/a |
|---|
| Components: | This complex has 2 components. |
|---|
| Component 1 |
| Name: | Programmed cell death protein 1 |
|---|
| Synonyms: | CD_antigen=CD279 | PD1 | PDCD1 | PDCD1_HUMAN | Programmed cell death protein 1 | Protein PD-1 | hPD-1 |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 31650.07 |
|---|
| Organism: | Homo sapiens |
|---|
| Description: | ChEMBL_108437 |
|---|
| Residue: | 288 |
|---|
| Sequence: | MQIPQAPWPVVWAVLQLGWRPGWFLDSPDRPWNPPTFSPALLVVTEGDNATFTCSFSNTS
ESFVLNWYRMSPSNQTDKLAAFPEDRSQPGQDCRFRVTQLPNGRDFHMSVVRARRNDSGT
YLCGAISLAPKAQIKESLRAELRVTERRAEVPTAHPSPSPRPAGQFQTLVVGVVGGLLGS
LVLLVWVLAVICSRAARGTIGARRTGQPLKEDPSAVPVFSVDYGELDFQWREKTPEPPVP
CVPEQTEYATIVFPSGMGTSSPARRGSADGPRSAQPLRPEDGHCSWPL
|
|
|
|---|
| Component 2 |
| Name: | Programmed cell death 1 ligand 1 |
|---|
| Synonyms: | B7 homolog 1 | B7-H1 | B7H1 | B7H1 | CD274 | CD_antigen=CD274 | PD-L1 | PD1L1_HUMAN | PDCD1 ligand 1 | PDCD1L1 | PDCD1LG1 | PDL1 | Programmed cell death 1 ligand 1 | Programmed death ligand 1 |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 33278.49 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_109807 |
|---|
| Residue: | 290 |
|---|
| Sequence: | MRIFAVFIFMTYWHLLNAFTVTVPKDLYVVEYGSNMTIECKFPVEKQLDLAALIVYWEME
DKNIIQFVHGEEDLKVQHSSYRQRARLLKDQLSLGNAALQITDVKLQDAGVYRCMISYGG
ADYKRITVKVNAPYNKINQRILVVDPVTSEHELTCQAEGYPKAEVIWTSSDHQVLSGKTT
TTNSKREEKLFNVTSTLRINTTTNEIFYCTFRRLDPEENHTAELVIPELPLAHPPNERTH
LVILGAILLCLGVALTFIFRLRKGRMMDVKKCGIQDTNSKKQSDTHLEET
|
|
|
|---|
| BDBM474554 |
|---|
| n/a |
|---|
| Name | BDBM474554 |
|---|
| Synonyms: | US10882844, Example 1014 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C43H44ClN5O5 |
|---|
| Mol. Mass. | 746.293 |
|---|
| SMILES | CN1C2CCC1CC(C2)c1nc2cc(ccc2o1)-c1cccc(COc2cc(OCc3cncc(c3)C#N)c(CN3CCCC[C@H]3C(O)=O)cc2Cl)c1C |r| |
|---|
| Structure | 
|
|---|
Search and Browse
