Reaction Details |
| Report a problem with these data |
Target | RAF proto-oncogene serine/threonine-protein kinase |
---|
Ligand | BDBM483966 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | Kinase Assay |
---|
IC50 | <0.1±n/a nM |
---|
Citation | Kaldor, SW; Kanouni, T; Arnold, L Inhibitors of RAF kinases US Patent US10927111 Publication Date 2/23/2021 |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
RAF proto-oncogene serine/threonine-protein kinase |
---|
Name: | RAF proto-oncogene serine/threonine-protein kinase |
Synonyms: | C-Raf Protein Kinase | Proto-oncogene c-RAF (RAF1) | RAF | RAF proto-oncogene
serine/threonine-protein kinase (C-Raf) | RAF1 | RAF1_HUMAN | Raf-1 | Serine/threonine-protein kinase
RAF | Serine/threonine-protein kinase C-Raf | cRaf |
Type: | Serine/threonine-protein kinase |
Mol. Mass.: | 73082.52 |
Organism: | Homo sapiens (Human) |
Description: | P04049 |
Residue: | 648 |
Sequence: | MEHIQGAWKTISNGFGFKDAVFDGSSCISPTIVQQFGYQRRASDDGKLTDPSKTSNTIRV
FLPNKQRTVVNVRNGMSLHDCLMKALKVRGLQPECCAVFRLLHEHKGKKARLDWNTDAAS
LIGEELQVDFLDHVPLTTHNFARKTFLKLAFCDICQKFLLNGFRCQTCGYKFHEHCSTKV
PTMCVDWSNIRQLLLFPNSTIGDSGVPALPSLTMRRMRESVSRMPVSSQHRYSTPHAFTF
NTSSPSSEGSLSQRQRSTSTPNVHMVSTTLPVDSRMIEDAIRSHSESASPSALSSSPNNL
SPTGWSQPKTPVPAQRERAPVSGTQEKNKIRPRGQRDSSYYWEIEASEVMLSTRIGSGSF
GTVYKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIV
TQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGL
TVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYE
LMTGELPYSHINNRDQIIFMVGRGYASPDLSKLYKNCPKAMKRLVADCVKKVKEERPLFP
QILSSIELLQHSLPKINRSASEPSLHRAAHTEDINACTLTTSPRLPVF
|
|
|
BDBM483966 |
---|
n/a |
---|
Name | BDBM483966 |
Synonyms: | (R)-N-(2-fluoro-4-methyl-5-(7-methyl- 2-(methylamino)pyrido[2,3- d]pyrimidin-6-yl)phenyl)-3- (trifluoromethyl)pyrrolidine-1- carboxamide | US10927111, Example 2 | US11667634, Example 2 |
Type | Small organic molecule |
Emp. Form. | C22H22F4N6O |
Mol. Mass. | 462.4433 |
SMILES | CNc1ncc2cc(c(C)nc2n1)-c1cc(NC(=O)N2CC[C@H](C2)C(F)(F)F)c(F)cc1C |r| |
Structure |
|