| Reaction Details |
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 | Report a problem with these data |
| Target | Beta-3 adrenergic receptor |
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| Ligand | BDBM484077 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Homogeneous Time-Resolved Fluorescence Assay |
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| IC50 | 28920±n/a nM |
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| Citation |  Tran, T; Do, Q; Ullman, B; Blackburn, AC; Nagura, M Modulators of the beta-3 adrenergic receptor useful for the treatment or prevention of disorders related thereto US Patent US10927123 Publication Date 2/23/2021 |
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| More Info.: | Get all data from this article, Assay Method |
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| Beta-3 adrenergic receptor |
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| Name: | Beta-3 adrenergic receptor |
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| Synonyms: | ADRB3 | ADRB3R | ADRB3_HUMAN | B3AR | Beta-2 adrenergic receptor and beta-3 adrenergic receptor | Beta-3 adrenoceptor | Beta-3 adrenoreceptor | adrenergic Beta3 |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 43534.88 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 408 |
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| Sequence: | MAPWPHENSSLAPWPDLPTLAPNTANTSGLPGVPWEAALAGALLALAVLATVGGNLLVIV
AIAWTPRLQTMTNVFVTSLAAADLVMGLLVVPPAATLALTGHWPLGATGCELWTSVDVLC
VTASIETLCALAVDRYLAVTNPLRYGALVTKRCARTAVVLVWVVSAAVSFAPIMSQWWRV
GADAEAQRCHSNPRCCAFASNMPYVLLSSSVSFYLPLLVMLFVYARVFVVATRQLRLLRG
ELGRFPPEESPPAPSRSLAPAPVGTCAPPEGVPACGRRPARLLPLREHRALCTLGLIMGT
FTLCWLPFFLANVLRALGGPSLVPGPAFLALNWLGYANSAFNPLIYCRSPDFRSAFRRLL
CRCGRRLPPEPCAAARPALFPSGVPAARSSPAQPRLCQRLDGASWGVS
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| BDBM484077 |
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| n/a |
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| Name | BDBM484077 |
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| Synonyms: | 3-((R)-3-((S)-3-(3- (cyclopropylsulfonyl) phenoxy)-2- hydroxypropylamino)-1- oxa-8-azaspiro[4.5]decan- 8-ylsulfonyl)-8- methylquinolin-4-ol | US10927123, Compound 327 |
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| Type | Small organic molecule |
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| Emp. Form. | C30H37N3O8S2 |
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| Mol. Mass. | 631.76 |
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| SMILES | Cc1cccc2c(O)c(cnc12)S(=O)(=O)N1CCC2(C[C@H](CO2)NC[C@H](O)COc2cccc(c2)S(=O)(=O)C2CC2)CC1 |r| |
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| Structure | 
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