| Reaction Details |
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 | Report a problem with these data |
| Target | AP-4 complex subunit sigma-1 |
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| Ligand | BDBM484181 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Human Sigma-1 Receptor Radioligand Assay |
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| Ki | <100±n/a nM |
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| Citation |  Virgili-Bernado, M; Almansa-Rosales, C; Alegret-Molina, C Oxadiazaspiro compounds for the treatment of drug abuse and addiction US Patent US10927128 Publication Date 2/23/2021 |
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| More Info.: | Get all data from this article, Assay Method |
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| AP-4 complex subunit sigma-1 |
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| Name: | AP-4 complex subunit sigma-1 |
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| Synonyms: | AP-4 complex subunit sigma-1 | AP4S1 | AP4S1_HUMAN | Sigma-1 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 17000.04 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Sigma-1 0 HUMAN::Q9Y587 |
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| Residue: | 144 |
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| Sequence: | MIKFFLMVNKQGQTRLSKYYEHVDINKRTLLETEVIKSCLSRSNEQCSFIEYKDFKLIYR
QYAALFIVVGVNDTENEMAIYEFIHNFVEVLDEYFSRVSELDIMFNLDKVHIILDEMVLN
GCIVETNRARILAPLLILDKMSES
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| BDBM484181 |
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| n/a |
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| Name | BDBM484181 |
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| Synonyms: | 2-(2-(12-isobutyl-4-oxa-8,12- diazadispiro[2.1.5.3]tridecan- 8-yl)ethyl)nicotinonitrile | US10927128, Example 102 | US11649248, Example 102 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H32N4O |
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| Mol. Mass. | 368.5157 |
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| SMILES | CC(C)CN1CC2(CC2)OC2(CCN(CCc3ncccc3C#N)CC2)C1 |
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| Structure | 
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