| Reaction Details |
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 | Report a problem with these data |
| Target | Glycogen synthase kinase-3 beta |
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| Ligand | BDBM484701 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Kinase Assay |
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| EC50 | 272±n/a nM |
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| Citation |  Kc, SK; Mak, CC; Mittapalli, GK; Hofilena, BJ; Eastman, BW; Cao, J; Chiruta, C; Bollu, V 5-heteroaryl substituted indazole-3-carboxamides and preparation and use thereof US Patent US10934297 Publication Date 3/2/2021 |
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| More Info.: | Get all data from this article, Assay Method |
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| Glycogen synthase kinase-3 beta |
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| Name: | Glycogen synthase kinase-3 beta |
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| Synonyms: | GSK-3 beta | GSK-3, beta | GSK3B | GSK3B_HUMAN | Glycogen synthase kinase 3 beta (GSK3B) | Glycogen synthase kinase 3-beta (GSK3B) | Glycogen synthase kinase-3 beta (GSK-3B) | Glycogen synthase kinase-3 beta (GSK3 Beta) | Glycogen synthase kinase-3 beta (GSK3B) | Glycogen synthase kinase-3B (GSK-3B) | Glycogen synthase kinase-3beta (GSK3B) | Serine/threonine-protein kinase GSK3B |
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| Type: | Enzyme |
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| Mol. Mass.: | 46756.38 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P49841 |
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| Residue: | 420 |
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| Sequence: | MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTK
VIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSG
EKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHR
DIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDV
WSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHP
WTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALF
NFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST
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| BDBM484701 |
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| n/a |
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| Name | BDBM484701 |
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| Synonyms: | US10934297, Compound 94 | US11713320, Compound 94 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H27FN8O |
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| Mol. Mass. | 474.5333 |
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| SMILES | Fc1cc2[nH]nc(C(=O)Nc3ccc(nc3)N3CCCC3)c2cc1-c1cnn(c1)C1CCNCC1 |
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| Structure | 
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