| Reaction Details |
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 | Report a problem with these data |
| Target | Serine hydroxymethyltransferase, cytosolic |
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| Ligand | BDBM285677 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Enzymatic Assay |
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| IC50 | 400±n/a nM |
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| Citation |  Rabinowitz, JD; Kim, H; Ducker, GS; Ghergurovich, JM SHMT inhibitors US Patent US10934305 Publication Date 3/2/2021 |
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| More Info.: | Get all data from this article, Assay Method |
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| Serine hydroxymethyltransferase, cytosolic |
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| Name: | Serine hydroxymethyltransferase, cytosolic |
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| Synonyms: | GLYC_HUMAN | Glycine hydroxymethyltransferase | SHMT | SHMT1 | Serine methylase |
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| Type: | PROTEIN |
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| Mol. Mass.: | 53091.10 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_745716 |
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| Residue: | 483 |
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| Sequence: | MTMPVNGAHKDADLWSSHDKMLAQPLKDSDVEVYNIIKKESNRQRVGLELIASENFASRA
VLEALGSCLNNKYSEGYPGQRYYGGTEFIDELETLCQKRALQAYKLDPQCWGVNVQPYSG
SPANFAVYTALVEPHGRIMGLDLPDGGHLTHGFMTDKKKISATSIFFESMPYKVNPDTGY
INYDQLEENARLFHPKLIIAGTSCYSRNLEYARLRKIADENGAYLMADMAHISGLVAAGV
VPSPFEHCHVVTTTTHKTLRGCRAGMIFYRKGVKSVDPKTGKEILYNLESLINSAVFPGL
QGGPHNHAIAGVAVALKQAMTLEFKVYQHQVVANCRALSEALTELGYKIVTGGSDNHLIL
VDLRSKGTDGGRAEKVLEACSIACNKNTCPGDRSALRPSGLRLGTPALTSRGLLEKDFQK
VAHFIHRGIELTLQIQSDTGVRATLKEFKERLAGDKYQAAVQALREEVESFASLFPLPGL
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| BDBM285677 |
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| n/a |
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| Name | BDBM285677 |
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| Synonyms: | US10077273, Compound HK-7 | US10934305, Compound HK-7 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H17ClN4O |
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| Mol. Mass. | 328.796 |
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| SMILES | CC(C)C1(c2c(C)n[nH]c2OC(N)=C1C#N)c1cccc(Cl)c1 |c:13| |
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| Structure | 
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