| Reaction Details |
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 | Report a problem with these data |
| Target | Neuroepithelial cell-transforming gene 1 protein |
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| Ligand | BDBM485767 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Binding Assay |
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| Ki | 300±n/a nM |
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| Citation |  Almansa-Rosales, C; Yenes-Mínguez, S; Virgili-Bernado, M; Alonso-Xalma, M Quinoline and isoquinoline derivatives for treating pain and pain related conditions US Patent US10941138 Publication Date 3/9/2021 |
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| More Info.: | Get all data from this article, Assay Method |
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| Neuroepithelial cell-transforming gene 1 protein |
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| Name: | Neuroepithelial cell-transforming gene 1 protein |
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| Synonyms: | ARHG8_HUMAN | ARHGEF8 | NET1 | Proto-oncogene p65 Net1 | Rho guanine nucleotide exchange factor 8 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 67762.41 |
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| Organism: | Homo sapiens |
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| Description: | ChEMBL_118125 |
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| Residue: | 596 |
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| Sequence: | MEPELAAQKQPRPRRRSRRASGLSTEGATGPSADTSGSELDGRCSLRRGSSFTFLTPGPN
WDFTLKRKRREKDDDVVSLSSLDLKEPSNKRVRPLARVTSLANLISPVRNGAVRRFGQTI
QSFTLRGDHRSPASAQKFSSRSTVPTPAKRRSSALWSEMLDITMKESLTTREIRRQEAIY
EMSRGEQDLIEDLKLARKAYHDPMLKLSIMSEEELTHIFGDLDSYIPLHEDLLTRIGEAT
KPDGTVEQIGHILVSWLPRLNAYRGYCSNQLAAKALLDQKKQDPRVQDFLQRCLESPFSR
KLDLWSFLDIPRSRLVKYPLLLKEILKHTPKEHPDVQLLEDAILIIQGVLSDINLKKGES
ECQYYIDKLEYLDEKQRDPRIEASKVLLCHGELRSKSGHKLYIFLFQDILVLTRPVTRNE
RHSYQVYRQPIPVQELVLEDLQDGDVRMGGSFRGAFSNSEKAKNIFRIRFHDPSPAQSHT
LQANDVFHKQQWFNCIRAAIAPFQSAGSPPELQGLPELHEECEGNHPSARKLTAQRRAST
VSSVTQVEVDENAYRCGSGMQMAEDSKSLKTHQTQPGIRRARDKALSGGKRKETLV
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| BDBM485767 |
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| n/a |
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| Name | BDBM485767 |
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| Synonyms: | (S)-N-methyl-3-((1- methylisoquinolin-5- yl)oxy)-3-(thiophen-2- yl)propan-1-amine | US10941138, Example 65 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H20N2OS |
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| Mol. Mass. | 312.429 |
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| SMILES | CNCC[C@H](Oc1cccc2c(C)nccc12)c1cccs1 |r| |
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| Structure | 
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