Reaction Details |
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Target | Isocitrate dehydrogenase [NADP], mitochondrial [R140Q] |
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Ligand | BDBM280218 |
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Substrate/Competitor | n/a |
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Meas. Tech. | In Vitro Assays for IDH2m R140Q Inhibitors |
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IC50 | <50±n/a nM |
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Citation | Konteatis, ZD; Popovici-Muller, J; Travins, J; Zahler, R; Cai, Z; Zhou, D Therapeutically active compounds and their methods of use US Patent US10946023 Publication Date 3/16/2021 |
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More Info.: | Get all data from this article, Assay Method |
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Isocitrate dehydrogenase [NADP], mitochondrial [R140Q] |
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Name: | Isocitrate dehydrogenase [NADP], mitochondrial [R140Q] |
Synonyms: | IDH2 | IDH2(R140Q) | IDHP_HUMAN | idh2 r140q |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 50823.17 |
Organism: | Homo sapiens (Human) |
Description: | P48735 (R140Q) |
Residue: | 452 |
Sequence: | MAGYLRVVRSLCRASGSRPAWAPAALTAPTSQEQPRRHYADKRIKVAKPVVEMDGDEMTR
IIWQFIKEKLILPHVDIQLKYFDLGLPNRDQTDDQVTIDSALATQKYSVAVKCATITPDE
ARVEEFKLKKMWKSPNGTIGNILGGTVFREPIICKNIPRLVPGWTKPITIGRHAHGDQYK
ATDFVADRAGTFKMVFTPKDGSGVKEWEVYNFPAGGVGMGMYNTDESISGFAHSCFQYAI
QKKWPLYMSTKNTILKAYDGRFKDIFQEIFDKHYKTDFDKNKIWYEHRLIDDMVAQVLKS
SGGFVWACKNYDGDVQSDILAQGFGSLGLMTSVLVCPDGKTIEAEAAHGTVTRHYREHQK
GRPTSTNPIASIFAWTRGLEHRGKLDGNQDLIRFAQMLEKVCVETVESGAMTKDLAGCIH
GLSNVKLNEHFLNTTDFLDTIKSNLDRALGRQ
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BDBM280218 |
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n/a |
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Name | BDBM280218 |
Synonyms: | US10028961, Compound 376 | US10172864, Compound 376 | US10946023, Compound 376 |
Type | Small organic molecule |
Emp. Form. | C22H18F5N9 |
Mol. Mass. | 503.4306 |
SMILES | FC(F)(F)c1ccnc(n1)-c1nc(N[C@H]2CCC(F)(F)C2)nc(Nc2ccnc(c2)C2(CC2)C#N)n1 |r| |
Structure |
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