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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Mitogen-activated protein kinase kinase kinase 12 | ||
| Ligand | BDBM301518 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | DLK TR-FRET Inhibition Assay | ||
| Ki | 4.92±n/a nM | ||
| Citation |  Estrada, A; Patel, S; Kellar, T; Huestis, M; Shore, D; Siu, M Tricyclic DLK inhibitors and uses thereof US Patent US10131675 Publication Date 11/20/2018 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Mitogen-activated protein kinase kinase kinase 12 | |||
| Name: | Mitogen-activated protein kinase kinase kinase 12 | ||
| Synonyms: | DLK | Dual leucine zipper bearing kinase | Leucine-zipper protein kinase | M3K12_HUMAN | MAP3K12 | MAPK-upstream kinase | MUK | Mitogen-activated protein kinase kinase kinase 12 | Mixed lineage kinase | ZPK | ||
| Type: | PROTEIN | ||
| Mol. Mass.: | 93216.56 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | ChEMBL_1460553 | ||
| Residue: | 859 | ||
| Sequence: |
| ||
| BDBM301518 | |||
| n/a | |||
| Name | BDBM301518 | ||
| Synonyms: | US10131675, Example 3 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C23H25N7O | ||
| Mol. Mass. | 415.4909 | ||
| SMILES | Cc1c[nH]c2ncc(cc12)-c1nc(N2CC3CC2C3)c2nc3n(CCOC3(C)C)c2n1 |(-6.24,-.74,;-5.47,-2.07,;-6.37,-3.32,;-5.47,-4.56,;-4,-4.09,;-2.67,-4.86,;-1.33,-4.09,;-1.33,-2.55,;-2.67,-1.78,;-4,-2.55,;,-1.78,;1.33,-2.55,;2.67,-1.78,;4,-2.55,;5.47,-2.07,;6.37,-3.32,;5.47,-4.56,;4,-4.09,;4.83,-3.32,;2.67,-.24,;3.81,.8,;3.19,2.2,;1.65,2.04,;.75,3.29,;1.37,4.69,;2.91,4.86,;3.81,3.61,;4.9,4.7,;5.3,3.21,;1.33,.53,;,-.24,)| | ||
| Structure | 
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