Search and Browse
Download
Enter Data
| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Mitogen-activated protein kinase kinase kinase 12 | ||
| Ligand | BDBM301630 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | DLK TR-FRET Inhibition Assay | ||
| Ki | 21.3±n/a nM | ||
| Citation |  Estrada, A; Patel, S; Kellar, T; Huestis, M; Shore, D; Siu, M Tricyclic DLK inhibitors and uses thereof US Patent US10131675 Publication Date 11/20/2018 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Mitogen-activated protein kinase kinase kinase 12 | |||
| Name: | Mitogen-activated protein kinase kinase kinase 12 | ||
| Synonyms: | DLK | Dual leucine zipper bearing kinase | Leucine-zipper protein kinase | M3K12_HUMAN | MAP3K12 | MAPK-upstream kinase | MUK | Mitogen-activated protein kinase kinase kinase 12 | Mixed lineage kinase | ZPK | ||
| Type: | PROTEIN | ||
| Mol. Mass.: | 93216.56 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | ChEMBL_1460553 | ||
| Residue: | 859 | ||
| Sequence: |
| ||
| BDBM301630 | |||
| n/a | |||
| Name | BDBM301630 | ||
| Synonyms: | US10131675, Example 116 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C20H23N7O | ||
| Mol. Mass. | 377.4429 | ||
| SMILES | CC1(C)OCCn2c1nc1c(nc(cc21)-c1cnc(N)nc1)N1CC2CC1C2 |(-4.81,.53,;-5.21,-.96,;-6.7,-.56,;-5.83,-2.37,;-4.93,-3.61,;-3.4,-3.45,;-2.77,-2.05,;-3.68,-.8,;-2.77,.45,;-1.31,-.03,;.03,.74,;1.36,-.03,;1.36,-1.57,;.03,-2.34,;-1.31,-1.57,;2.69,-2.34,;2.69,-3.88,;4.03,-4.65,;5.36,-3.88,;6.7,-4.65,;5.36,-2.34,;4.03,-1.57,;.03,2.28,;-1.22,3.19,;-.74,4.65,;.8,4.65,;1.27,3.19,;.03,3.32,)| | ||
| Structure | 
| ||