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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Mitogen-activated protein kinase kinase kinase 12 | ||
| Ligand | BDBM301657 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | DLK TR-FRET Inhibition Assay | ||
| Ki | 2.23±n/a nM | ||
| Citation |  Estrada, A; Patel, S; Kellar, T; Huestis, M; Shore, D; Siu, M Tricyclic DLK inhibitors and uses thereof US Patent US10131675 Publication Date 11/20/2018 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Mitogen-activated protein kinase kinase kinase 12 | |||
| Name: | Mitogen-activated protein kinase kinase kinase 12 | ||
| Synonyms: | DLK | Dual leucine zipper bearing kinase | Leucine-zipper protein kinase | M3K12_HUMAN | MAP3K12 | MAPK-upstream kinase | MUK | Mitogen-activated protein kinase kinase kinase 12 | Mixed lineage kinase | ZPK | ||
| Type: | PROTEIN | ||
| Mol. Mass.: | 93216.56 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | ChEMBL_1460553 | ||
| Residue: | 859 | ||
| Sequence: |
| ||
| BDBM301657 | |||
| n/a | |||
| Name | BDBM301657 | ||
| Synonyms: | US10131675, Example 144 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C22H23N7O | ||
| Mol. Mass. | 401.4643 | ||
| SMILES | CC1(C)OCCn2c1nc1c(nc(cc21)-c1cnc(N)c(c1)C#N)N1CC2CC1C2 |(-6.27,.53,;-5.87,-.96,;-7.36,-.56,;-6.5,-2.37,;-5.6,-3.61,;-4.06,-3.45,;-3.44,-2.05,;-4.34,-.8,;-3.44,.45,;-1.97,-.03,;-.64,.74,;.69,-.03,;.69,-1.57,;-.64,-2.34,;-1.97,-1.57,;2.03,-2.34,;2.03,-3.88,;3.36,-4.65,;4.7,-3.88,;6.03,-4.65,;4.7,-2.34,;3.36,-1.57,;6.03,-1.57,;7.36,-.8,;-.64,2.28,;-1.89,3.19,;-1.41,4.65,;.13,4.65,;.61,3.19,;-.64,3.32,)| | ||
| Structure | 
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