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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Mitogen-activated protein kinase kinase kinase 12 | ||
| Ligand | BDBM301659 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | DLK TR-FRET Inhibition Assay | ||
| Ki | 32.2±n/a nM | ||
| Citation |  Estrada, A; Patel, S; Kellar, T; Huestis, M; Shore, D; Siu, M Tricyclic DLK inhibitors and uses thereof US Patent US10131675 Publication Date 11/20/2018 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Mitogen-activated protein kinase kinase kinase 12 | |||
| Name: | Mitogen-activated protein kinase kinase kinase 12 | ||
| Synonyms: | DLK | Dual leucine zipper bearing kinase | Leucine-zipper protein kinase | M3K12_HUMAN | MAP3K12 | MAPK-upstream kinase | MUK | Mitogen-activated protein kinase kinase kinase 12 | Mixed lineage kinase | ZPK | ||
| Type: | PROTEIN | ||
| Mol. Mass.: | 93216.56 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | ChEMBL_1460553 | ||
| Residue: | 859 | ||
| Sequence: |
| ||
| BDBM301659 | |||
| n/a | |||
| Name | BDBM301659 | ||
| Synonyms: | US10131675, Example 146 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C21H22N8O | ||
| Mol. Mass. | 402.4524 | ||
| SMILES | CC1(C)OCCn2c1nc1c(nc(nc21)-c1cnc2[nH]cnc2c1)N1CC2CC1C2 |(6.17,1.48,;5.4,2.82,;6.88,3.22,;5.24,4.35,;3.83,4.98,;2.58,4.07,;2.74,2.54,;4.15,1.91,;3.99,.38,;2.48,.06,;1.71,-1.27,;.17,-1.27,;-.6,.06,;.17,1.39,;1.71,1.39,;-2.14,.06,;-2.91,1.39,;-4.45,1.39,;-5.22,.06,;-6.72,-.26,;-6.88,-1.79,;-5.48,-2.42,;-4.45,-1.27,;-2.91,-1.27,;2.48,-2.61,;4.02,-2.61,;4.5,-4.07,;3.25,-4.98,;2.01,-4.07,;3.1,-2.98,)| | ||
| Structure | 
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