| Reaction Details |
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 | Report a problem with these data |
| Target | PAS domain-containing serine/threonine-protein kinase [879-1323] |
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| Ligand | BDBM487209 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Kinase Luminescence Assay |
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| IC50 | >10000±n/a nM |
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| Citation |  McCall, JM; Kelly, RC; Romero, DL Heterocyclic compounds for the inhibition of pask US Patent US10953012 Publication Date 3/23/2021 |
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| More Info.: | Get all data from this article, Assay Method |
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| PAS domain-containing serine/threonine-protein kinase [879-1323] |
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| Name: | PAS domain-containing serine/threonine-protein kinase [879-1323] |
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| Synonyms: | KIAA0135 | PAS domain-containing serine/threonine-protein kinase (PASK) (879-1323) | PASK | PASK_HUMAN |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 49711.83 |
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| Organism: | Homo sapiens (Human) |
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| Description: | aa 879-1323 |
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| Residue: | 445 |
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| Sequence: | MRGAAGLQREIQEGAYSGSCYHRDGLRLSIQFEVRRVELQGPTPLFCCWLVKDLLHSQRD
SAARTRLFLASLPGSTHSTAAELTGPSLVEVLRARPWFEEPPKAVELEGLAACEGEYSQK
YSTMSPLGSGAFGFVWTAVDKEKNKEVVVKFIKKEKVLEDCWIEDPKLGKVTLEIAILSR
VEHANIIKVLDIFENQGFFQLVMEKHGSGLDLFAFIDRHPRLDEPLASYIFRQLVSAVGY
LRLKDIIHRDIKDENIVIAEDFTIKLIDFGSAAYLERGKLFYTFCGTIEYCAPEVLMGNP
YRGPELEMWSLGVTLYTLVFEENPFCELEETVEAAIHPPYLVSKELMSLVSGLLQPVPER
RTTLEKLVTDPWVTQPVNLADYTWEEVFRVNKPESGVLSAASLEMGNRSLSDVAQAQELC
GGPVPGEAPNGQGCLHPGDPRLLTS
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| BDBM487209 |
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| n/a |
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| Name | BDBM487209 |
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| Synonyms: | 2,3-Diphenyl-6,7-dihydro-4H-cyclopenta[d]pyrazolo[1,5-a]pyrimidin-8(5H)-one | US10953012, Example 35 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H17N3O |
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| Mol. Mass. | 327.3792 |
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| SMILES | O=c1c2CCCc2[nH]c2c(c(nn12)-c1ccccc1)-c1ccccc1 |
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| Structure | 
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