Reaction Details | |||
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Target | Tyrosine-protein kinase JAK1 | ||
Ligand | BDBM159783 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | Caliper Enzyme Assay | ||
IC50 | 9.00±n/a nM | ||
Citation | Vazquez, ML; Kaila, N; Tuttle, JB; Verhoest, PR; Reese, MR; Coffman, KJ; Samad, T; Duerr, JM; Sciabola, S; Parikh, MD Pyrrolo[2,3-d]pyrimidine derivatives US Patent US10966980 Publication Date 4/6/2021 | ||
More Info.: | Get all data from this article, Assay Method | ||
Tyrosine-protein kinase JAK1 | |||
Name: | Tyrosine-protein kinase JAK1 | ||
Synonyms: | JAK-1 | JAK1 | JAK1A | JAK1B | JAK1_HUMAN | Janus kinase 1 | Janus kinase 1 (JAK1) | Janus kinase 1 JAK1 | ||
Type: | Protein | ||
Mol. Mass.: | 133293.73 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P23458 | ||
Residue: | 1154 | ||
Sequence: |
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BDBM159783 | |||
n/a | |||
Name | BDBM159783 | ||
Synonyms: | US10966980, Example 34B | US9035074, 34B | ||
Type | Small organic molecule | ||
Emp. Form. | C18H23N5O2S | ||
Mol. Mass. | 373.473 | ||
SMILES | CN([C@@H]1C[C@H](CS(=O)(=O)[C@H]2CC[C@@H](C2)C#N)C1)c1ncnc2[nH]ccc12 |r,wU:12.14,wD:2.1,4.4,9.8,(-7.01,1.61,;-5.68,.84,;-4.34,1.61,;-3.94,3.09,;-2.46,2.69,;-1.12,3.47,;.21,2.69,;-.88,1.61,;1.3,3.78,;1.54,1.93,;1.56,.38,;3.03,-.1,;3.93,1.15,;3.03,2.4,;5.47,1.15,;7.01,1.15,;-2.86,1.21,;-5.68,-.7,;-7.01,-1.47,;-7.01,-3.01,;-5.68,-3.78,;-4.34,-3.01,;-2.88,-3.49,;-1.97,-2.24,;-2.88,-1,;-4.34,-1.47,)| | ||
Structure |