Search and Browse
Download
Enter Data
| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Tyrosine-protein kinase JAK1 | ||
| Ligand | BDBM489920 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Caliper Enzyme Assay | ||
| IC50 | 0.008±n/a nM | ||
| Citation |  Vazquez, ML; Kaila, N; Tuttle, JB; Verhoest, PR; Reese, MR; Coffman, KJ; Samad, T; Duerr, JM; Sciabola, S; Parikh, MD Pyrrolo[2,3-d]pyrimidine derivatives US Patent US10966980 Publication Date 4/6/2021 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Tyrosine-protein kinase JAK1 | |||
| Name: | Tyrosine-protein kinase JAK1 | ||
| Synonyms: | JAK-1 | JAK1 | JAK1A | JAK1B | JAK1_HUMAN | Janus kinase 1 | Janus kinase 1 (JAK1) | Janus kinase 1 JAK1 | ||
| Type: | Protein | ||
| Mol. Mass.: | 133293.73 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P23458 | ||
| Residue: | 1154 | ||
| Sequence: |
| ||
| BDBM489920 | |||
| n/a | |||
| Name | BDBM489920 | ||
| Synonyms: | US10966980, Example 174 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C16H23FN4O2S | ||
| Mol. Mass. | 354.443 | ||
| SMILES | CN([C@@H]1C[C@H](CS(=O)(=O)CCCCF)C1)c1ncnc2[nH]ccc12 |r,wD:2.1,4.4,(-6.39,.19,;-5.06,-.58,;-3.97,.5,;-3.97,2.04,;-2.43,2.04,;-1.34,3.13,;.15,2.73,;-.25,1.25,;1.48,1.96,;1.24,3.82,;2.73,3.43,;3.81,4.51,;5.3,4.12,;6.39,5.2,;-2.43,.5,;-5.06,-2.12,;-6.39,-2.89,;-6.39,-4.43,;-5.06,-5.2,;-3.72,-4.43,;-2.26,-4.91,;-1.35,-3.66,;-2.26,-2.42,;-3.72,-2.89,)| | ||
| Structure | 
| ||