Reaction Details | |||
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Target | Tyrosine-protein kinase JAK1 | ||
Ligand | BDBM489971 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | Caliper Enzyme Assay | ||
IC50 | 0.008±n/a nM | ||
Citation | Vazquez, ML; Kaila, N; Tuttle, JB; Verhoest, PR; Reese, MR; Coffman, KJ; Samad, T; Duerr, JM; Sciabola, S; Parikh, MD Pyrrolo[2,3-d]pyrimidine derivatives US Patent US10966980 Publication Date 4/6/2021 | ||
More Info.: | Get all data from this article, Assay Method | ||
Tyrosine-protein kinase JAK1 | |||
Name: | Tyrosine-protein kinase JAK1 | ||
Synonyms: | JAK-1 | JAK1 | JAK1A | JAK1B | JAK1_HUMAN | Janus kinase 1 | Janus kinase 1 (JAK1) | Janus kinase 1 JAK1 | ||
Type: | Protein | ||
Mol. Mass.: | 133293.73 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P23458 | ||
Residue: | 1154 | ||
Sequence: |
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BDBM489971 | |||
n/a | |||
Name | BDBM489971 | ||
Synonyms: | US10966980, Example 225 | ||
Type | Small organic molecule | ||
Emp. Form. | C19H23N5O3S | ||
Mol. Mass. | 401.483 | ||
SMILES | CCOc1ncccc1S(=O)(=O)C[C@H]1C[C@H](C1)N(C)c1ncnc2[nH]ccc12 |r,wD:15.18,13.13,(3.72,6.4,;2.23,6,;1.84,4.51,;2.92,3.43,;4.41,3.82,;5.5,2.73,;5.1,1.25,;3.61,.85,;2.53,1.94,;1.04,1.54,;1.44,3.03,;.64,.05,;-.45,1.94,;-1.54,.85,;-3.08,.85,;-3.08,-.69,;-1.54,-.69,;-4.17,-1.78,;-5.5,-1.01,;-4.17,-3.32,;-5.5,-4.09,;-5.5,-5.63,;-4.17,-6.4,;-2.83,-5.63,;-1.37,-6.11,;-.46,-4.86,;-1.37,-3.61,;-2.83,-4.09,)| | ||
Structure |