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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Tyrosine-protein kinase JAK1 | ||
| Ligand | BDBM490003 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Caliper Enzyme Assay | ||
| IC50 | 0.009±n/a nM | ||
| Citation |  Vazquez, ML; Kaila, N; Tuttle, JB; Verhoest, PR; Reese, MR; Coffman, KJ; Samad, T; Duerr, JM; Sciabola, S; Parikh, MD Pyrrolo[2,3-d]pyrimidine derivatives US Patent US10966980 Publication Date 4/6/2021 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Tyrosine-protein kinase JAK1 | |||
| Name: | Tyrosine-protein kinase JAK1 | ||
| Synonyms: | JAK-1 | JAK1 | JAK1A | JAK1B | JAK1_HUMAN | Janus kinase 1 | Janus kinase 1 (JAK1) | Janus kinase 1 JAK1 | ||
| Type: | Protein | ||
| Mol. Mass.: | 133293.73 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P23458 | ||
| Residue: | 1154 | ||
| Sequence: |
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| BDBM490003 | |||
| n/a | |||
| Name | BDBM490003 | ||
| Synonyms: | US10966980, Example 257 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C21H29N7O2S | ||
| Mol. Mass. | 443.566 | ||
| SMILES | CN([C@@H]1C[C@H](CS(=O)(=O)N2Cc3cn(C)nc3C(C)(C)C2)C1)c1ncnc2[nH]ccc12 |r,wU:2.1,4.4,(4.45,4.1,;3.68,2.77,;2.14,2.77,;1.05,3.86,;-.04,2.77,;-1.58,2.77,;-2.35,1.44,;-1.01,.67,;-3.68,2.21,;-3.12,.1,;-4.66,.1,;-5.43,-1.23,;-6.93,-1.55,;-7.09,-3.08,;-8.43,-3.85,;-5.69,-3.71,;-4.66,-2.56,;-3.12,-2.56,;-3.12,-4.1,;-1.78,-3.33,;-2.35,-1.23,;1.05,1.68,;4.45,1.44,;3.68,.1,;4.45,-1.23,;5.99,-1.23,;6.76,.1,;8.27,.42,;8.43,1.95,;7.02,2.58,;5.99,1.44,)| | ||
| Structure | 
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