| Reaction Details |
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 | Report a problem with these data |
| Target | Myeloperoxidase |
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| Ligand | BDBM492834 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | MPO Peroxidation (Amplex Red) Assay |
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| IC50 | 10.00±n/a nM |
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| Citation |  Viet, AQ; Wurtz, NR Thioether triazolopyridine and triazolopyrimidine inhibitors of myeloperoxidase US Patent US10981879 Publication Date 4/20/2021 |
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| More Info.: | Get all data from this article, Assay Method |
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| Myeloperoxidase |
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| Name: | Myeloperoxidase |
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| Synonyms: | 84 kDa myeloperoxidase | 89 kDa myeloperoxidase | MPO | Mpo protein | Myeloperoxidase | Myeloperoxidase (MPO) | Myeloperoxidase heavy chain | Myeloperoxidase light chain | PERM_HUMAN |
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| Type: | Enzyme |
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| Mol. Mass.: | 83888.32 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P05164 |
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| Residue: | 745 |
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| Sequence: | MGVPFFSSLRCMVDLGPCWAGGLTAEMKLLLALAGLLAILATPQPSEGAAPAVLGEVDTS
LVLSSMEEAKQLVDKAYKERRESIKQRLRSGSASPMELLSYFKQPVAATRTAVRAADYLH
VALDLLERKLRSLWRRPFNVTDVLTPAQLNVLSKSSGCAYQDVGVTCPEQDKYRTITGMC
NNRRSPTLGASNRAFVRWLPAEYEDGFSLPYGWTPGVKRNGFPVALARAVSNEIVRFPTD
QLTPDQERSLMFMQWGQLLDHDLDFTPEPAARASFVTGVNCETSCVQQPPCFPLKIPPND
PRIKNQADCIPFFRSCPACPGSNITIRNQINALTSFVDASMVYGSEEPLARNLRNMSNQL
GLLAVNQRFQDNGRALLPFDNLHDDPCLLTNRSARIPCFLAGDTRSSEMPELTSMHTLLL
REHNRLATELKSLNPRWDGERLYQEARKIVGAMVQIITYRDYLPLVLGPTAMRKYLPTYR
SYNDSVDPRIANVFTNAFRYGHTLIQPFMFRLDNRYQPMEPNPRVPLSRVFFASWRVVLE
GGIDPILRGLMATPAKLNRQNQIAVDEIRERLFEQVMRIGLDLPALNMQRSRDHGLPGYN
AWRRFCGLPQPETVGQLGTVLRNLKLARKLMEQYGTPNNIDIWMGGVSEPLKRKGRVGPL
LACIIGTQFRKLRDGDRFWWENEGVFSMQQRQALAQISLPRIICDNTGITTVSKNNIFMS
NSYPRDFVNCSTLPALNLASWREAS
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| BDBM492834 |
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| n/a |
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| Name | BDBM492834 |
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| Synonyms: | 7-((2,5-difluoro-4-(1,2,4- oxadiazol-3-yl)benzyl)thio)- 3H-[1,2,3]triazolo[4,5-b] pyridin-5-amine | US10981879, Example 28 |
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| Type | Small organic molecule |
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| Emp. Form. | C14H9F2N7OS |
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| Mol. Mass. | 361.329 |
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| SMILES | Nc1cc(SCc2cc(F)c(cc2F)-c2ncon2)c2nn[nH]c2n1 |
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| Structure | 
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