| Reaction Details |
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 | Report a problem with these data |
| Target | AP2-associated protein kinase 1 |
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| Ligand | BDBM311268 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | AAK1 Kinase Assay |
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| IC50 | 1.20±n/a nM |
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| Citation |  Luo, G; Dzierba, CD; Macor, JE Biaryl kinase inhibitors US Patent US10981910 Publication Date 4/20/2021 |
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| More Info.: | Get all data from this article, Assay Method |
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| AP2-associated protein kinase 1 |
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| Name: | AP2-associated protein kinase 1 |
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| Synonyms: | AAK1 | AAK1_HUMAN | Adaptor-associated kinase 1 | KIAA1048 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 103884.23 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_774569 |
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| Residue: | 961 |
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| Sequence: | MKKFFDSRREQGGSGLGSGSSGGGGSTSGLGSGYIGRVFGIGRQQVTVDEVLAEGGFAIV
FLVRTSNGMKCALKRMFVNNEHDLQVCKREIQIMRDLSGHKNIVGYIDSSINNVSSGDVW
EVLILMDFCRGGQVVNLMNQRLQTGFTENEVLQIFCDTCEAVARLHQCKTPIIHRDLKVE
NILLHDRGHYVLCDFGSATNKFQNPQTEGVNAVEDEIKKYTTLSYRAPEMVNLYSGKIIT
TKADIWALGCLLYKLCYFTLPFGESQVAICDGNFTIPDNSRYSQDMHCLIRYMLEPDPDK
RPDIYQVSYFSFKLLKKECPIPNVQNSPIPAKLPEPVKASEAAAKKTQPKARLTDPIPTT
ETSIAPRQRPKAGQTQPNPGILPIQPALTPRKRATVQPPPQAAGSSNQPGLLASVPQPKP
QAPPSQPLPQTQAKQPQAPPTPQQTPSTQAQGLPAQAQATPQHQQQLFLKQQQQQQQPPP
AQQQPAGTFYQQQQAQTQQFQAVHPATQKPAIAQFPVVSQGGSQQQLMQNFYQQQQQQQQ
QQQQQQLATALHQQQLMTQQAALQQKPTMAAGQQPQPQPAAAPQPAPAQEPAIQAPVRQQ
PKVQTTPPPAVQGQKVGSLTPPSSPKTQRAGHRRILSDVTHSAVFGVPASKSTQLLQAAA
AEASLNKSKSATTTPSGSPRTSQQNVYNPSEGSTWNPFDDDNFSKLTAEELLNKDFAKLG
EGKHPEKLGGSAESLIPGFQSTQGDAFATTSFSAGTAEKRKGGQTVDSGLPLLSVSDPFI
PLQVPDAPEKLIEGLKSPDTSLLLPDLLPMTDPFGSTSDAVIEKADVAVESLIPGLEPPV
PQRLPSQTESVTSNRTDSLTGEDSLLDCSLLSNPTTDLLEEFAPTAISAPVHKAAEDSNL
ISGFDVPEGSDKVAEDEFDPIPVLITKNPQGGHSRNSSGSSESSLPNLARSLLLVDQLID
L
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| BDBM311268 |
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| n/a |
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| Name | BDBM311268 |
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| Synonyms: | (S)-1-((2′,4-bis(difluoromethyl)-[2,4′-bipyridin]-5-yl)oxy)-2,4-dimethylpentan-2-amine | US10155760, Example 124 | US10351563, Example 124 | US10544120, Example 124 | US10723734, Example 124 | US10981910, Example 124 | US9902722, Example 124 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H23F4N3O |
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| Mol. Mass. | 385.399 |
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| SMILES | CC(C)C[C@](C)(N)COc1cnc(cc1C(F)F)-c1ccnc(c1)C(F)F |r| |
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| Structure | 
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