| Reaction Details |
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 | Report a problem with these data |
| Target | Non-receptor tyrosine-protein kinase TYK2 [871-1187] |
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| Ligand | BDBM103737 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | TYK2 Inhibition Assay |
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| IC50 | 126±n/a nM |
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| Citation |  Menet, CJ; Smits, KK Compound useful for the treatment of degenerative and inflammatory diseases US Patent US11000528 Publication Date 5/11/2021 |
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| More Info.: | Get all data from this article, Assay Method |
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| Non-receptor tyrosine-protein kinase TYK2 [871-1187] |
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| Name: | Non-receptor tyrosine-protein kinase TYK2 [871-1187] |
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| Synonyms: | Non-receptor tyrosine-protein kinase TYK2 | Non-receptor tyrosine-protein kinase TYK2 (871-1187) | TYK2 | TYK2 (aa 871-1187) | TYK2_HUMAN |
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| Type: | Protein |
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| Mol. Mass.: | 36255.07 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P29597[871-1187] |
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| Residue: | 317 |
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| Sequence: | PHNLADVLTVNPDSPASDPTVFHKRYLKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVK
ALKADCGPQHRSGWKQEIDILRTLYHEHIIKYKGCCEDQGEKSLQLVMEYVPLGSLRDYL
PRHSIGLAQLLLFAQQICEGMAYLHAQHYIHRDLAARNVLLDNDRLVKIGDFGLAKAVPE
GHEYYRVREDGDSPVFWYAPECLKEYKFYYASDVWSFGVTLYELLTHCDSSQSPPTKFLE
LIGIAQGQMTVLRLTELLERGERLPRPDKCPCEVYHLMKNCWETEASFRPTFENLIPILK
TVHEKYQGQAPSVFSVC
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| BDBM103737 |
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| n/a |
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| Name | BDBM103737 |
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| Synonyms: | US10206907, Compound 234 | US11000528, Cpd # 11 | US8563545, 11 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H23F2N5O |
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| Mol. Mass. | 411.4477 |
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| SMILES | FC1(F)CCN(Cc2ccc(cc2)-c2cccc3nc(NC(=O)C4CC4)nn23)CC1 |
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| Structure | 
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