| Reaction Details |
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 | Report a problem with these data |
| Target | Glutaminyl-peptide cyclotransferase |
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| Ligand | BDBM7886 |
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| Substrate/Competitor | BDBM7883 |
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| Meas. Tech. | QC Inhibition Testing |
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| pH | 8±n/a |
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| Temperature | 303.15±n/a K |
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| Ki | 4600000±38000 nM |
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| Citation |  Buchholz, M; Heiser, U; Schilling, S; Niestroj, AJ; Zunkel, K; Demuth, HU The first potent inhibitors for human glutaminyl cyclase: synthesis and structure-activity relationship. J Med Chem49:664-77 (2006) [PubMed] Article |
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| More Info.: | Get all data from this article, Inhibition_Run data, Solution Info, Assay Method |
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| Glutaminyl-peptide cyclotransferase |
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| Name: | Glutaminyl-peptide cyclotransferase |
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| Synonyms: | Glutaminyl Cyclase | Glutaminyl cyclase (QC) | Glutaminyl-peptide cyclotransferase | Glutaminyl-peptide cyclotransferase precursor (QC) | Glutaminyl-tRNA cyclotransferase | Glutamyl cyclase (QC) | QPCT | QPCT_HUMAN |
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| Type: | Enzyme |
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| Mol. Mass.: | 40877.05 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q16769 |
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| Residue: | 361 |
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| Sequence: | MAGGRHRRVVGTLHLLLLVAALPWASRGVSPSASAWPEEKNYHQPAILNSSALRQIAEGT
SISEMWQNDLQPLLIERYPGSPGSYAARQHIMQRIQRLQADWVLEIDTFLSQTPYGYRSF
SNIISTLNPTAKRHLVLACHYDSKYFSHWNNRVFVGATDSAVPCAMMLELARALDKKLLS
LKTVSDSKPDLSLQLIFFDGEEAFLHWSPQDSLYGSRHLAAKMASTPHPPGARGTSQLHG
MDLLVLLDLIGAPNPTFPNFFPNSARWFERLQAIEHELHELGLLKDHSLEGRYFQNYSYG
GVIQDDHIPFLRRGVPVLHLIPSPFPEVWHTMDDNEENLDESTIDNLNKILQVFVLEYLH
L
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| BDBM7886 |
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| BDBM7883 |
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| Name | BDBM7886 |
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| Synonyms: | 1-PIM | 1-phenyl-1H-imidazole | 1-phenylimidazole | CHEMBL275066 | US9138393, 1-Phenyl- imidazole | US9144538, 1-Phenylimidazole |
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| Type | Small organic molecule |
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| Emp. Form. | C9H8N2 |
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| Mol. Mass. | 144.1732 |
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| SMILES | c1cn(cn1)-c1ccccc1 |
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| Structure | 
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