| Reaction Details |
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 | Report a problem with these data |
| Target | Thioredoxin reductase 1, cytoplasmic |
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| Ligand | BDBM501860 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Inhibition Assay |
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| IC50 | 26.8±n/a nM |
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| Citation |  Pelcman, B; Suna, E; Stafford, W; Priede, M Heteroarylsulfonyl-substituted pyridines and their use in the treatment of cancer US Patent US11028067 Publication Date 6/8/2021 |
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| More Info.: | Get all data from this article, Assay Method |
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| Thioredoxin reductase 1, cytoplasmic |
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| Name: | Thioredoxin reductase 1, cytoplasmic |
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| Synonyms: | GRIM-12 | GRIM12 | Gene associated with retinoid-IFN-induced mortality 12 protein | KDRF | KM-102-derived reductase-like factor | TR | TRXR1_HUMAN | TXNRD1 | Thioredoxin reductase 1 | Thioredoxin reductase 1 (TrxR) | Thioredoxin reductase TR1 |
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| Type: | Protein |
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| Mol. Mass.: | 70761.78 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q16881 |
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| Residue: | 648 |
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| Sequence: | MGCAEGKAVAAAAPTELQTKGKNGDGRRRSAKDHHPGKTLPENPAGFTSTATADSRALLQ
AYIDGHSVVIFSRSTCTRCTEVKKLFKSLCVPYFVLELDQTEDGRALEGTLSELAAETDL
PVVFVKQRKIGGHGPTLKAYQEGRLQKLLKMNGPEDLPKSYDYDLIIIGGGSGGLAAAKE
AAQYGKKVMVLDFVTPTPLGTRWGLGGTCVNVGCIPKKLMHQAALLGQALQDSRNYGWKV
EETVKHDWDRMIEAVQNHIGSLNWGYRVALREKKVVYENAYGQFIGPHRIKATNNKGKEK
IYSAERFLIATGERPRYLGIPGDKEYCISSDDLFSLPYCPGKTLVVGASYVALECAGFLA
GIGLDVTVMVRSILLRGFDQDMANKIGEHMEEHGIKFIRQFVPIKVEQIEAGTPGRLRVV
AQSTNSEEIIEGEYNTVMLAIGRDACTRKIGLETVGVKINEKTGKIPVTDEEQTNVPYIY
AIGDILEDKVELTPVAIQAGRLLAQRLYAGSTVKCDYENVPTTVFTPLEYGACGLSEEKA
VEKFGEENIEVYHSYFWPLEWTIPSRDNNKCYAKIICNTKDNERVVGFHVLGPNAGEVTQ
GFAAALKCGLTKKQLDSTIGIHPVCAEVFTTLSVTKRSGASILQAGCG
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| BDBM501860 |
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| n/a |
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| Name | BDBM501860 |
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| Synonyms: | US11028067, Example 1 | US11028067, Example 8 |
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| Type | Small organic molecule |
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| Emp. Form. | C11H9N3O5S |
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| Mol. Mass. | 295.271 |
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| SMILES | COc1ccc(c(n1)S(=O)(=O)c1ccccn1)[N+]([O-])=O |
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| Structure | 
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