| Reaction Details |
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 | Report a problem with these data |
| Target | Enoyl-[acyl-carrier-protein] reductase [NADPH] FabI |
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| Ligand | BDBM302046 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Enzyme Inhibition Assay |
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| IC50 | 821±n/a nM |
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| Citation |  Guillemont, JE; Lançois, DF; Motte, MM; Koul, A; Balemans, WM Antibacterial piperidinyl substituted 3,4-dihydro-1H-[1,8]naphthyridinones US Patent US9598407 Publication Date 3/21/2017 |
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| More Info.: | Get all data from this article, Assay Method |
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| Enoyl-[acyl-carrier-protein] reductase [NADPH] FabI |
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| Name: | Enoyl-[acyl-carrier-protein] reductase [NADPH] FabI |
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| Synonyms: | Enoyl-[acyl-carrier-protein] reductase [NADPH] FabI | Enoyl-acyl carrier protein reductase (FaBI) | FABI_STAA8 | NADPH-dependent enoyl-ACP reductase (FabI) | fabI |
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| Type: | Enzyme |
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| Mol. Mass.: | 28019.03 |
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| Organism: | Staphylococcus aureus |
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| Description: | Q2FZQ3 |
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| Residue: | 256 |
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| Sequence: | MLNLENKTYVIMGIANKRSIAFGVAKVLDQLGAKLVFTYRKERSRKELEKLLEQLNQPEA
HLYQIDVQSDEEVINGFEQIGKDVGNIDGVYHSIAFANMEDLRGRFSETSREGFLLAQDI
SSYSLTIVAHEAKKLMPEGGSIVATTYLGGEFAVQNYNVMGVAKASLEANVKYLALDLGP
DNIRVNAISASPIRTLSAKGVGGFNTILKEIEERAPLKRNVDQVEVGKTAAYLLSDLSSG
VTGENIHVDSGFHAIK
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| BDBM302046 |
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| n/a |
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| Name | BDBM302046 |
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| Synonyms: | US9598407, Compound 2 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H23N3O3 |
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| Mol. Mass. | 389.447 |
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| SMILES | COc1ccccc1C1=CCN(CC1)C(=O)\C=C\c1cnc2NC(=O)CCc2c1 |t:9| |
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| Structure | 
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