| Reaction Details |
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 | Report a problem with these data |
| Target | RNA-binding protein FXR1 |
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| Ligand | BDBM504311 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | AlphaScreen Assay |
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| EC50 | 29.0±5 nM |
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| Citation |  Pellicciari, R; Gioiello, A Farnesoid X receptor modulators US Patent US11034717 Publication Date 6/15/2021 |
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| More Info.: | Get all data from this article, Assay Method |
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| RNA-binding protein FXR1 |
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| Name: | RNA-binding protein FXR1 |
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| Synonyms: | FXR1 | FXR1_HUMAN | Fragile X mental retardation syndrome-related protein 1 | hFXR1p |
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| Type: | Protein |
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| Mol. Mass.: | 69715.95 |
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| Organism: | Human |
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| Description: | P51114 |
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| Residue: | 621 |
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| Sequence: | MAELTVEVRGSNGAFYKGFIKDVHEDSLTVVFENNWQPERQVPFNEVRLPPPPDIKKEIS
EGDEVEVYSRANDQEPCGWWLAKVRMMKGEFYVIEYAACDATYNEIVTFERLRPVNQNKT
VKKNTFFKCTVDVPEDLREACANENAHKDFKKAVGACRIFYHPETTQLMILSASEATVKR
VNILSDMHLRSIRTKLMLMSRNEEATKHLECTKQLAAAFHEEFVVREDLMGLAIGTHGSN
IQQARKVPGVTAIELDEDTGTFRIYGESADAVKKARGFLEFVEDFIQVPRNLVGKVIGKN
GKVIQEIVDKSGVVRVRIEGDNENKLPREDGMVPFVFVGTKESIGNVQVLLEYHIAYLKE
VEQLRMERLQIDEQLRQIGSRSYSGRGRGRRGPNYTSGYGTNSELSNPSETESERKDELS
DWSLAGEDDRDSRHQRDSRRRPGGRGRSVSGGRGRGGPRGGKSSISSVLKDPDSNPYSLL
DNTESDQTADTDASESHHSTNRRRRSRRRRTDEDAVLMDGMTESDTASVNENGLVTVADY
ISRAESQSRQRNLPRETLAKNKKEMAKDVIEEHGPSEKAINGPTSASGDDISKLQRTPGE
EKINTLKEENTQEAAVLNGVS
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| BDBM504311 |
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| n/a |
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| Name | BDBM504311 |
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| Synonyms: | 3α,7α,11β-trihydroxy-6α-ethyl-23-(1,2,4-oxadiazol-5-oxo-3-yl)-23-nor-5β-cholane | US11034717, Compound 7 |
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| Type | Small organic molecule |
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| Emp. Form. | C27H44N2O5 |
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| Mol. Mass. | 476.6487 |
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| SMILES | CC[C@H]1[C@@H](O)C2C3CC[C@H]([C@H](C)CCc4nc(=O)o[nH]4)[C@@]3(C)C[C@H](O)C2[C@@]2(C)CC[C@@H](O)C[C@@H]12 |r| |
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| Structure | 
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