| Reaction Details |
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 | Report a problem with these data |
| Target | Platelet-derived growth factor receptor alpha [D842V] |
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| Ligand | BDBM504400 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Biochemical Activity Assay |
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| IC50 | <1±n/a nM |
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| Citation |  Hodous, BL; Kim, JL; Wilson, KJ Substituted pyrrolo[1,2-b]pyridazines for treating disorders related to KIT and PDGFR US Patent US11040979 Publication Date 6/22/2021 |
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| More Info.: | Get all data from this article, Assay Method |
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| Platelet-derived growth factor receptor alpha [D842V] |
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| Name: | Platelet-derived growth factor receptor alpha [D842V] |
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| Synonyms: | PDGFR2 | PDGFRA | PGFRA_HUMAN | Platelet-derived growth factor receptor (D842V) | Platelet-derived growth factor receptor alpha (PDGFR)(D842V) | Platelet-derived growth factor receptor alpha (PDGFRα)(D842V) | RHEPDGFRA |
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| Type: | Protein |
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| Mol. Mass.: | 122618.43 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P16234 (D842V) |
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| Residue: | 1089 |
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| Sequence: | MGTSHPAFLVLGCLLTGLSLILCQLSLPSILPNENEKVVQLNSSFSLRCFGESEVSWQYP
MSEEESSDVEIRNEENNSGLFVTVLEVSSASAAHTGLYTCYYNHTQTEENELEGRHIYIY
VPDPDVAFVPLGMTDYLVIVEDDDSAIIPCRTTDPETPVTLHNSEGVVPASYDSRQGFNG
TFTVGPYICEATVKGKKFQTIPFNVYALKATSELDLEMEALKTVYKSGETIVVTCAVFNN
EVVDLQWTYPGEVKGKGITMLEEIKVPSIKLVYTLTVPEATVKDSGDYECAARQATREVK
EMKKVTISVHEKGFIEIKPTFSQLEAVNLHEVKHFVVEVRAYPPPRISWLKNNLTLIENL
TEITTDVEKIQEIRYRSKLKLIRAKEEDSGHYTIVAQNEDAVKSYTFELLTQVPSSILDL
VDDHHGSTGGQTVRCTAEGTPLPDIEWMICKDIKKCNNETSWTILANNVSNIITEIHSRD
RSTVEGRVTFAKVEETIAVRCLAKNLLGAENRELKLVAPTLRSELTVAAAVLVLLVIVII
SLIVLVVIWKQKPRYEIRWRVIESISPDGHEYIYVDPMQLPYDSRWEFPRDGLVLGRVLG
SGAFGKVVEGTAYGLSRSQPVMKVAVKMLKPTARSSEKQALMSELKIMTHLGPHLNIVNL
LGACTKSGPIYIITEYCFYGDLVNYLHKNRDSFLSHHPEKPKKELDIFGLNPADESTRSY
VILSFENNGDYMDMKQADTTQYVPMLERKEVSKYSDIQRSLYDRPASYKKKSMLDSEVKN
LLSDDNSEGLTLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLAQGKIVKICDFGLA
RVIMHDSNYVSKGSTFLPVKWMAPESIFDNLYTTLSDVWSYGILLWEIFSLGGTPYPGMM
VDSTFYNKIKSGYRMAKPDHATSEVYEIMVKCWNSEPEKRPSFYHLSEIVENLLPGQYKK
SYEKIHLDFLKSDHPAVARMRVDSDNAYIGVTYKNEEDKLKDWEGGLDEQRLSADSGYII
PLPDIDPVPEEEDLGKRNRHSSQTSEESAIETGSSSSTFIKREDETIEDIDMMDDIGIDS
SDLVEDSFL
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| BDBM504400 |
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| n/a |
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| Name | BDBM504400 |
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| Synonyms: | (S)-4-(4-(5-(1-amino-1-(4-fluorophenyl)ethyl)pyrimidin-2-yl)piperazin-1-yl)-6-(1-methyl-1H-pyrazol-4-yl)pyrrolo[1,2-b]pyridazine-3-carbonitrile | US11040979, Compound 4 |
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| Type | Small organic molecule |
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| Emp. Form. | C28H27FN10 |
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| Mol. Mass. | 522.5794 |
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| SMILES | Cn1cc(cn1)-c1cc2c(N3CCN(CC3)c3ncc(cn3)[C@@](C)(N)c3ccc(F)cc3)c(cnn2c1)C#N |r| |
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| Structure | 
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