| Reaction Details |
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 | Report a problem with these data |
| Target | Sentrin-specific protease/Small ubiquitin-related modifier 2 |
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| Ligand | BDBM103826 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Enzyme Kinetic Assay |
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| IC50 | 1100±5800 nM |
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| Citation |  Chen, Y; Chen, C; Namanja, A Methods of identifying SENP1 inhibitors US Patent US11041859 Publication Date 6/22/2021 |
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| More Info.: | Get all data from this article, Assay Method |
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| Sentrin-specific protease/Small ubiquitin-related modifier 2 |
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| Name: | Sentrin-specific protease/Small ubiquitin-related modifier 2 |
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| Synonyms: | SUMO2/SENP2 |
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| Type: | Protein |
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| Mol. Mass.: | n/a |
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| Description: | n/a |
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| Components: | This complex has 2 components. |
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| Component 1 |
| Name: | Small ubiquitin-related modifier 2 |
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| Synonyms: | SMT3B | SMT3H2 | SUMO2 | SUMO2_HUMAN | Small ubiquitin-related modifier 2 |
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| Type: | Protein |
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| Mol. Mass.: | 10869.09 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 95 |
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| Sequence: | MADEKPKEGVKTENNDHINLKVAGQDGSVVQFKIKRHTPLSKLMKAYCERQGLSMRQIRF
RFDGQPINETDTPAQLEMEDEDTIDVFQQQTGGVY
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| Component 2 |
| Name: | Sentrin-specific protease 2 |
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| Synonyms: | KIAA1331 | SENP2 | SENP2_HUMAN | Sentrin-specific protease 2 (SENP2) |
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| Type: | Protein |
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| Mol. Mass.: | 67890.62 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9HC62 |
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| Residue: | 589 |
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| Sequence: | MYRWLVRILGTIFRFCDRSVPPARALLKRRRSDSTLFSTVDTDEIPAKRPRLDCFIHQVK
NSLYNAASLFGFPFQLTTKPMVTSACNGTRNVAPSGEVFSNSSSCELTGSGSWNNMLKLG
NKSPNGISDYPKIRVTVTRDQPRRVLPSFGFTLNSEGCNRRPGGRRHSKGNPESSLMWKP
QEQAVTEMISEESGKGLRRPHCTVEEGVQKEEREKYRKLLERLKESGHGNSVCPVTSNYH
SSQRSQMDTLKTKGWGEEQNHGVKTTQFVPKQYRLVETRGPLCSLRSEKRCSKGKITDTE
TMVGIRFENESRRGYQLEPDLSEEVSARLRLGSGSNGLLRRKVSIIETKEKNCSGKERDR
RTDDLLELTEDMEKEISNALGHGPQDEILSSAFKLRITRGDIQTLKNYHWLNDEVINFYM
NLLVERNKKQGYPALHVFSTFFYPKLKSGGYQAVKRWTKGVNLFEQEIILVPIHRKVHWS
LVVIDLRKKCLKYLDSMGQKGHRICEILLQYLQDESKTKRNSDLNLLEWTHHSMKPHEIP
QQLNGSDCGMFTCKYADYISRDKPITFTQHQMPLFRKKMVWEILHQQLL
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| BDBM103826 |
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| n/a |
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| Name | BDBM103826 |
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| Synonyms: | SPI-01 | US11041859, Code SPI-01 | US9791447, Compound SPI-01 |
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| Type | Small organic molecule |
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| Emp. Form. | C34H26N6O6S2 |
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| Mol. Mass. | 678.737 |
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| SMILES | Nc1ccc2ccccc2c1\N=N\c1ccc(\C=C\c2ccc(cc2S(O)(=O)=O)\N=N\c2c(N)ccc3ccccc23)c(c1)S(O)(=O)=O |
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| Structure | 
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