| Reaction Details |
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 | Report a problem with these data |
| Target | Sentrin-specific protease/Small ubiquitin-related modifier 2 |
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| Ligand | BDBM103827 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Enzyme Kinetic Assay |
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| IC50 | 2700±2100 nM |
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| Citation |  Chen, Y; Chen, C; Namanja, A Methods of identifying SENP1 inhibitors US Patent US11041859 Publication Date 6/22/2021 |
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| More Info.: | Get all data from this article, Assay Method |
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| Sentrin-specific protease/Small ubiquitin-related modifier 2 |
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| Name: | Sentrin-specific protease/Small ubiquitin-related modifier 2 |
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| Synonyms: | SUMO2/SENP2 |
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| Type: | Protein |
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| Mol. Mass.: | n/a |
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| Description: | n/a |
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| Components: | This complex has 2 components. |
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| Component 1 |
| Name: | Small ubiquitin-related modifier 2 |
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| Synonyms: | SMT3B | SMT3H2 | SUMO2 | SUMO2_HUMAN | Small ubiquitin-related modifier 2 |
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| Type: | Protein |
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| Mol. Mass.: | 10869.09 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 95 |
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| Sequence: | MADEKPKEGVKTENNDHINLKVAGQDGSVVQFKIKRHTPLSKLMKAYCERQGLSMRQIRF
RFDGQPINETDTPAQLEMEDEDTIDVFQQQTGGVY
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| Component 2 |
| Name: | Sentrin-specific protease 2 |
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| Synonyms: | KIAA1331 | SENP2 | SENP2_HUMAN | Sentrin-specific protease 2 (SENP2) |
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| Type: | Protein |
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| Mol. Mass.: | 67890.62 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9HC62 |
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| Residue: | 589 |
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| Sequence: | MYRWLVRILGTIFRFCDRSVPPARALLKRRRSDSTLFSTVDTDEIPAKRPRLDCFIHQVK
NSLYNAASLFGFPFQLTTKPMVTSACNGTRNVAPSGEVFSNSSSCELTGSGSWNNMLKLG
NKSPNGISDYPKIRVTVTRDQPRRVLPSFGFTLNSEGCNRRPGGRRHSKGNPESSLMWKP
QEQAVTEMISEESGKGLRRPHCTVEEGVQKEEREKYRKLLERLKESGHGNSVCPVTSNYH
SSQRSQMDTLKTKGWGEEQNHGVKTTQFVPKQYRLVETRGPLCSLRSEKRCSKGKITDTE
TMVGIRFENESRRGYQLEPDLSEEVSARLRLGSGSNGLLRRKVSIIETKEKNCSGKERDR
RTDDLLELTEDMEKEISNALGHGPQDEILSSAFKLRITRGDIQTLKNYHWLNDEVINFYM
NLLVERNKKQGYPALHVFSTFFYPKLKSGGYQAVKRWTKGVNLFEQEIILVPIHRKVHWS
LVVIDLRKKCLKYLDSMGQKGHRICEILLQYLQDESKTKRNSDLNLLEWTHHSMKPHEIP
QQLNGSDCGMFTCKYADYISRDKPITFTQHQMPLFRKKMVWEILHQQLL
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| BDBM103827 |
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| n/a |
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| Name | BDBM103827 |
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| Synonyms: | SPI-02 | US11041859, Code SPI-02 | US9791447, Compound SPI-02 |
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| Type | Small organic molecule |
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| Emp. Form. | C34H28N6O9S3 |
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| Mol. Mass. | 760.816 |
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| SMILES | Cc1cc(ccc1\N=N\c1c(N)ccc2cc(ccc12)S(O)(=O)=O)-c1ccc(\N=N\c2c(N)c(cc3cc(ccc23)S(O)(=O)=O)S(O)(=O)=O)c(C)c1 |
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| Structure | 
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