| Reaction Details |
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 | Report a problem with these data |
| Target | Indoleamine 2,3-dioxygenase 1 |
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| Ligand | BDBM506770 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | IDO1 Cell-Based Assay |
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| IC50 | 0.970±n/a nM |
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| Citation |  Lewis, RT; Hamilton, M; Jones, P; Petrocchi, A; Reyna, N; McAfoos, T; Cross, JB; Soth, MJ Compounds useful as inhibitors of indoleamine 2,3-dioxygenase and/or tryptophan dioxygenase US Patent US11046649 Publication Date 6/29/2021 |
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| More Info.: | Get all data from this article, Assay Method |
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| Indoleamine 2,3-dioxygenase 1 |
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| Name: | Indoleamine 2,3-dioxygenase 1 |
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| Synonyms: | I23O1_HUMAN | IDO | IDO-1 | IDO1 | INDO | Indoleamine 2,3-Dioxygenasae (IDO) | Indoleamine 2,3-dioxygenase | Indoleamine-pyrrole 2,3-dioxygenase |
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| Type: | Enzyme |
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| Mol. Mass.: | 45330.80 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P14902 |
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| Residue: | 403 |
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| Sequence: | MAHAMENSWTISKEYHIDEEVGFALPNPQENLPDFYNDWMFIAKHLPDLIESGQLRERVE
KLNMLSIDHLTDHKSQRLARLVLGCITMAYVWGKGHGDVRKVLPRNIAVPYCQLSKKLEL
PPILVYADCVLANWKKKDPNKPLTYENMDVLFSFRDGDCSKGFFLVSLLVEIAAASAIKV
IPTVFKAMQMQERDTLLKALLEIASCLEKALQVFHQIHDHVNPKAFFSVLRIYLSGWKGN
PQLSDGLVYEGFWEDPKEFAGGSAGQSSVFQCFDVLLGIQQTAGGGHAAQFLQDMRRYMP
PAHRNFLCSLESNPSVREFVLSKGDAGLREAYDACVKALVSLRSYHLQIVTKYILIPASQ
QPKENKTSEDPSKLEAKGTGGTDLMNFLKTVRSTTEKSLLKEG
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| BDBM506770 |
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| n/a |
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| Name | BDBM506770 |
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| Synonyms: | N-(1-(difluoromethyl)-1H- pyrazol-4-yl)-2- ((1R,3s,5S,6r)-3-((6- fluoroquinolin-4-yl)oxy)- bicyclo[3.1.0]hexan-6- yl)butanamide | US11046649, Ex. 148 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H23F3N4O2 |
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| Mol. Mass. | 444.4495 |
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| SMILES | CCC([C@@H]1[C@H]2C[C@@H](C[C@@H]12)Oc1ccnc2ccc(F)cc12)C(=O)Nc1cnn(c1)C(F)F |r| |
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| Structure | 
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